How outcome switching is rendering clinical trials meaningless

Many researchers indulge in what is known as ‘outcome switching,’ which means the trial report does not include outcomes that are part of the pre-registration, or includes new outcomes without any underlying explanation. Switching of outcomes can have an impact on healthcare and scientific advancement. Why are journal editors and trial sponsors unable to put a stop to this phenomenon? Could accurate reporting in clinical trials help in countering the reproducibility crisis that science is facing? This post discusses these and more vital questions related to clinical trial reporting.