{"id":2204,"date":"2026-09-18T00:22:04","date_gmt":"2026-09-17T18:52:04","guid":{"rendered":"https:\/\/www.editage.com\/blog\/?p=2204"},"modified":"2026-09-09T08:05:32","modified_gmt":"2026-09-09T02:35:32","slug":"blinding-in-research-types-examples-and-best-practices","status":"publish","type":"post","link":"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/","title":{"rendered":"Blinding in Research: Types, Examples, and Best Practices"},"content":{"rendered":"<ul>\n<li>Blinding, also called masking, hides group assignment from 1 or more parties in a study so that expectations cannot distort behavior, measurement, or judgment.<\/li>\n<li>Single-blinding conceals allocation from participants; double-blinding also conceals it from investigators; triple-blinding extends concealment to a 3rd party such as outcome assessors, data analysts, or the monitoring committee.<\/li>\n<li>Blinding also governs peer review, where single-blind, double-blind, and triple-blind models control different combinations of author, reviewer, and editor bias.<\/li>\n<li>Blinding is not always feasible or successful: researchers must report who was blinded, how the blind was maintained, and whether it held.<\/li>\n<\/ul>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_Blinding_in_Research\" >What Is Blinding in Research?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Why_Does_Blinding_Matter\" >Why Does Blinding Matter?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Types_of_Blinding_in_Research\" >Types of Blinding in Research<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Open-Label_Studies_When_Blinding_Is_Not_Used\" >Open-Label Studies: When Blinding Is Not Used<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_Single-Blinding\" >What Is Single-Blinding?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_Double-Blinding\" >What Is Double-Blinding?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_Triple-Blinding\" >What Is Triple-Blinding?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Quadruple-Blinding_and_Registry_Categories\" >Quadruple-Blinding and Registry Categories<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Blinding_Methods_and_Techniques\" >Blinding Methods and Techniques<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Roles_to_Blind_and_the_Bias_Each_Step_Prevents\" >Roles to Blind and the Bias Each Step Prevents<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Blinding_in_Peer_Review\" >Blinding in Peer Review<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Does_Double-Blind_Peer_Review_Work\" >Does Double-Blind Peer Review Work?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Limitations_and_Risks_of_Blinding\" >Limitations and Risks of Blinding<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Testing_Whether_Blinding_Worked\" >Testing Whether Blinding Worked<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#How_Should_Blinding_Be_Reported\" >How Should Blinding Be Reported?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Frequently_Asked_Questions\" >Frequently Asked Questions<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_the_Difference_Between_Single-Blind_and_Double-Blind_Studies\" >What Is the Difference Between Single-Blind and Double-Blind Studies?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_the_Difference_Between_Blinding_and_Randomization\" >What Is the Difference Between Blinding and Randomization?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Can_a_Study_Be_Double-Blind_Without_a_Placebo\" >Can a Study Be Double-Blind Without a Placebo?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Is_a_Triple-Blind_Study_in_Psychology\" >What Is a Triple-Blind Study in Psychology?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Why_Is_Blinding_Not_Possible_in_Surgical_Trials\" >Why Is Blinding Not Possible in Surgical Trials?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#What_Does_Open-Label_Mean_in_a_Clinical_Trial\" >What Does Open-Label Mean in a Clinical Trial?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Is_Double-Blind_Peer_Review_Better_Than_Single-Blind_Peer_Review\" >Is Double-Blind Peer Review Better Than Single-Blind Peer Review?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#How_Do_You_Blind_a_Manuscript_for_Double-Blind_Review\" >How Do You Blind a Manuscript for Double-Blind Review?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#Glossary\" >Glossary<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/#References\" >References<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Is_Blinding_in_Research\"><\/span>What Is Blinding in Research?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Blinding is the practice of hiding group assignment from 1 or more parties in a study, so that knowing who received what cannot bias behavior, measurement, or interpretation. It is also called masking.<\/p>\n<p>The term is used in 2 related settings. In clinical, <a href=\"https:\/\/www.editage.com\/blog\/types-of-experimental-research-designs\/\">experimental<\/a>, and behavioral research, blinding keeps treatment allocation secret from participants and study staff. In scholarly publishing, blinding keeps identities secret from reviewers, authors, or editors.<\/p>\n<ul>\n<li>Blinding is not the same as randomization: randomization decides who goes where, while blinding decides who is allowed to know.<\/li>\n<li>Blinding is not the same as allocation concealment: concealment protects the enrollment step; blinding protects everything after it.<\/li>\n<li>Blinding is a spectrum, not a switch: a study may blind 1 role fully and another only partially.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Why_Does_Blinding_Matter\"><\/span>Why Does Blinding Matter?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Blinding matters because expectations change outcomes. It limits performance, detection, attrition, and analysis bias, which protects the <a href=\"https:\/\/www.editage.com\/blog\/internal-validity-external-validity-definition-differences-examples\/#What_Is_Internal_Validity\">internal validity<\/a> of the effect estimate a study reports.<\/p>\n<p>Unblinded <a href=\"https:\/\/www.editage.com\/blog\/randomized-controlled-trial-rct\/\">clinical trials<\/a> tend to report larger treatment effects than blinded trials of the same question, especially for subjective endpoints such as pain, fatigue, mood, and quality of life.<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"113\"><strong>Bias<\/strong><\/td>\n<td width=\"291\"><strong>What happens without blinding<\/strong><\/td>\n<td width=\"220\"><strong>How blinding responds<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"113\">Performance bias<\/td>\n<td width=\"291\">Staff or participants change behavior once they learn the assignment; the treated arm may receive extra attention or co-interventions.<\/td>\n<td width=\"220\">Blind participants and care providers.<\/td>\n<\/tr>\n<tr>\n<td width=\"113\">Detection bias<\/td>\n<td width=\"291\">Assessors read ambiguous findings in the direction they expect, such as scoring a borderline scan as improved.<\/td>\n<td width=\"220\">Blind outcome assessors and adjudication committees.<\/td>\n<\/tr>\n<tr>\n<td width=\"113\">Attrition bias<\/td>\n<td width=\"291\">Participants who suspect they received placebo drop out at higher rates, unbalancing the groups.<\/td>\n<td width=\"220\">Blinding evens dropout across arms.<\/td>\n<\/tr>\n<tr>\n<td width=\"113\">Analysis bias<\/td>\n<td width=\"291\">Analysts choose models, cut-points, or subgroups after seeing which arm is winning.<\/td>\n<td width=\"220\">Blind the statistician; label arms only as A and B.<\/td>\n<\/tr>\n<tr>\n<td width=\"113\">Expectation effect<\/td>\n<td width=\"291\">Belief in receiving an active treatment improves self-reported symptoms on its own.<\/td>\n<td width=\"220\">Pair a placebo control with blinding to separate the true effect.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Types_of_Blinding_in_Research\"><\/span>Types of Blinding in Research<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Blinding levels are named for the number of parties kept unaware. The table below summarizes the 5 levels most often reported, from no blinding to registry-style quadruple blinding.<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"100\"><strong>Level<\/strong><\/td>\n<td width=\"167\"><strong>Who is blinded<\/strong><\/td>\n<td width=\"193\"><strong>Typical example<\/strong><\/td>\n<td width=\"164\"><strong>Main limitation<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"100\">Open-label<\/td>\n<td width=\"167\">Nobody<\/td>\n<td width=\"193\">Surgery compared with 12 weeks of physiotherapy for knee pain<\/td>\n<td width=\"164\">High risk of performance and detection bias<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Single-blind<\/td>\n<td width=\"167\">Participants only<\/td>\n<td width=\"193\">Real acupuncture compared with sham acupuncture<\/td>\n<td width=\"164\">Staff expectations still leak through tone and attention<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Double-blind<\/td>\n<td width=\"167\">Participants and investigators<\/td>\n<td width=\"193\">Placebo-controlled tablet trial for hypertension<\/td>\n<td width=\"164\">Distinctive side effects can break the blind<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Triple-blind<\/td>\n<td width=\"167\">Participants, investigators, plus assessors or analysts<\/td>\n<td width=\"193\">Cardiovascular trial with a blinded endpoint adjudication committee<\/td>\n<td width=\"164\">Complex, costly, and defined inconsistently across journals<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Quadruple-blind<\/td>\n<td width=\"167\">Participant, care provider, investigator, and outcomes assessor<\/td>\n<td width=\"193\">Large vaccine efficacy trial registered with 4 masked roles<\/td>\n<td width=\"164\">Slower emergency response; heavy logistics<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Open-Label_Studies_When_Blinding_Is_Not_Used\"><\/span>Open-Label Studies: When Blinding Is Not Used<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>No blinding is acceptable when masking is impossible, unsafe, or unnecessary: for example, surgical versus nonsurgical care, or trials with hard endpoints such as death that leave little room for judgment.<\/p>\n<ul>\n<li>Common open-label settings: surgery, physical therapy, devices, dietary programs, and behavioral counseling.<\/li>\n<li>Hard endpoints reduce, but do not remove, the risk: patients may still seek different care once they know the assignment.<\/li>\n<li>Best practice: even when participants cannot be blinded, blind the outcome assessor and the statistician.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_Single-Blinding\"><\/span>What Is Single-Blinding?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>In a single-blind study, 1 party, usually the participant, does not know the assigned group. The investigators and delivery staff know the allocation and act on it.<\/p>\n<p>Single-blinding is chosen when the intervention cannot be hidden from the person delivering it, such as a physical maneuver, a device setting, or a therapist-led session.<\/p>\n<h4>Examples of single-blinding:<\/h4>\n<ul>\n<li>A trial of sham acupuncture where needles are retractable: the participant cannot tell real from sham, but the practitioner obviously can.<\/li>\n<li>A sleep study where participants are unaware whether they received a light-therapy lamp or a filtered control lamp.<\/li>\n<li>A consumer taste test where the brand labels are removed for tasters but known to the staff pouring the samples.<\/li>\n<li>A physiotherapy trial where patients do not know whether their exercise program is the experimental protocol or standard care.<\/li>\n<\/ul>\n<h4>Strengths and limits:<\/h4>\n<ul>\n<li>Strength: it removes participant expectation effects, which matter most for self-reported outcomes.<\/li>\n<li>Strength: it is cheaper and simpler than higher levels of blinding.<\/li>\n<li>Limit: staff may signal the assignment through tone, timing, extra encouragement, or unequal follow-up.<\/li>\n<li>Limit: unblinded investigators may score subjective endpoints inconsistently between arms.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_Double-Blinding\"><\/span>What Is Double-Blinding?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Double-blinding conceals the assignment from 2 parties: the participants and the investigators who deliver treatment or record outcomes. Neither side knows who received the active intervention.<\/p>\n<p>This is the standard for drug trials because a matched placebo makes the arms look, taste, and feel identical. Treatment kits carry code numbers, and the randomization list sits with an independent pharmacy or central system.<\/p>\n<h4>Examples of double-blinding:<\/h4>\n<ul>\n<li>A placebo-controlled statin trial where all bottles are identical and coded by kit number.<\/li>\n<li>A vaccine trial in which the syringe is prepared by an unblinded pharmacist and administered by blinded staff.<\/li>\n<li>A double-dummy trial comparing a tablet with an injection: every participant receives 1 active form and 1 matching placebo form.<\/li>\n<li>A nutrition trial using capsules of an active oil and a color-matched, odor-matched control oil.<\/li>\n<\/ul>\n<h4>Strengths and limits:<\/h4>\n<ul>\n<li>Strength: it controls participant expectation and clinician performance bias at the same time.<\/li>\n<li>Strength: it is widely required by regulators and by high-impact journals for efficacy claims.<\/li>\n<li>Limit: distinctive side effects, taste, or laboratory changes can unblind participants and clinicians.<\/li>\n<li>Limit: the label is used loosely; surveys of clinicians and journal editors have found several conflicting definitions of the same term.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_Triple-Blinding\"><\/span>What Is Triple-Blinding?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Triple-blinding conceals the assignment from 3 parties: participants, investigators, and a 3rd group, most often the outcome assessors, the data analysts, or the data monitoring committee.<\/p>\n<p>The 3rd layer targets the stages where judgment enters after data collection: endpoint adjudication, statistical modeling, and interim decision-making. Arms are usually labeled only as Group A and Group B until the analysis plan is locked.<\/p>\n<h4>Examples of triple-blinding:<\/h4>\n<ul>\n<li>A cardiology trial where an independent committee adjudicates every suspected heart attack without seeing the treatment arm.<\/li>\n<li>An imaging trial where a radiologist reads all scans in random order with the arm labels stripped from the file.<\/li>\n<li>A trial where the statistician analyzes coded arms and writes the report before the code is revealed.<\/li>\n<li>A trial where even the monitoring committee reviews pooled safety data under coded labels until a pre-set threshold is crossed.<\/li>\n<\/ul>\n<h4>Strengths and limits:<\/h4>\n<ul>\n<li>Strength: it protects the most judgment-heavy steps of a study, where small choices can move a <a href=\"https:\/\/www.editage.com\/blog\/p-value-statistics-hypothesis-testing-definition-meaning\/\">p-value.<\/a><\/li>\n<li>Strength: blinded analysis lets the team finalize the statistical plan without knowing which arm it favors.<\/li>\n<li>Limit: definitions vary; some authors mean assessors, others mean analysts, and others mean the monitoring committee.<\/li>\n<li>Limit: it adds cost, staffing, and delay, and it can slow the response to an emerging safety signal.<\/li>\n<li>Fix: never rely on the label alone. State exactly which 3 roles were masked.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Quadruple-Blinding_and_Registry_Categories\"><\/span>Quadruple-Blinding and Registry Categories<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Trial registries avoid the counting problem by listing masked roles instead of levels. A registration record simply checks the roles that were masked, which makes 4 the practical maximum in most systems.<\/p>\n<ul>\n<li>Participant<\/li>\n<li>Care provider<\/li>\n<li>Investigator<\/li>\n<li>Outcomes assessor<\/li>\n<\/ul>\n<p>A study masking all 4 roles is recorded as quadruple. Reporting roles rather than numbers removes most of the ambiguity around the words double and triple.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Blinding_Methods_and_Techniques\"><\/span>Blinding Methods and Techniques<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Researchers blind studies with matched placebos, identical packaging, coded kit numbers, central randomization, sham procedures, and independent assessors who never see treatment records.<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"140\"><strong>Technique<\/strong><\/td>\n<td width=\"260\"><strong>How it works<\/strong><\/td>\n<td width=\"224\"><strong>Example<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"140\">Matched placebo<\/td>\n<td width=\"260\">The control is manufactured to match the active product in size, color, taste, smell, and weight.<\/td>\n<td width=\"224\">An identical white tablet with no active ingredient<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Active placebo<\/td>\n<td width=\"260\">The control reproduces a noticeable side effect so participants cannot guess from how they feel.<\/td>\n<td width=\"224\">A low-dose agent that causes mild dry mouth<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Double-dummy<\/td>\n<td width=\"260\">Each participant receives 1 active and 1 placebo form so that 2 delivery routes stay indistinguishable.<\/td>\n<td width=\"224\">Active tablet plus placebo inhaler versus placebo tablet plus active inhaler<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Central randomization<\/td>\n<td width=\"260\">A remote system assigns codes, so no site staff member can see or predict the sequence.<\/td>\n<td width=\"224\">Interactive web response system issuing kit numbers<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Coded labelling<\/td>\n<td width=\"260\">Packaging shows a kit number only, with the key held by an independent pharmacy.<\/td>\n<td width=\"224\">Bottle marked 0147 rather than by drug name<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Sham device or procedure<\/td>\n<td width=\"260\">An inactive device or mock step mimics the experience of the real one.<\/td>\n<td width=\"224\">A deactivated stimulation unit with working indicator lights<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Blinded assessment<\/td>\n<td width=\"260\">Endpoints are scored by staff with no contact with treatment records.<\/td>\n<td width=\"224\">An off-site radiologist reading anonymized scans<\/td>\n<\/tr>\n<tr>\n<td width=\"140\">Blinded analysis<\/td>\n<td width=\"260\">The statistician receives arms labeled A and B and locks the plan before unblinding.<\/td>\n<td width=\"224\">Coded dataset released after database lock<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Roles_to_Blind_and_the_Bias_Each_Step_Prevents\"><\/span>Roles to Blind and the Bias Each Step Prevents<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Blind every role whose judgment or behavior could shift the result. The table below maps roles to the bias each masking step prevents.<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"120\"><strong>Role<\/strong><\/td>\n<td width=\"293\"><strong>Why blind this role<\/strong><\/td>\n<td width=\"211\"><strong>Bias prevented<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"120\">Participant<\/td>\n<td width=\"293\">Belief about treatment changes symptom reporting, adherence, and dropout.<\/td>\n<td width=\"211\">Expectation and attrition bias<\/td>\n<\/tr>\n<tr>\n<td width=\"120\">Care provider<\/td>\n<td width=\"293\">Knowledge invites unequal attention, dose changes, and extra co-interventions.<\/td>\n<td width=\"211\">Performance bias<\/td>\n<\/tr>\n<tr>\n<td width=\"120\">Investigator<\/td>\n<td width=\"293\">Knowledge shapes eligibility judgments and follow-up intensity.<\/td>\n<td width=\"211\">Performance and selection bias<\/td>\n<\/tr>\n<tr>\n<td width=\"120\">Outcome assessor<\/td>\n<td width=\"293\">Ambiguous findings get read in the expected direction.<\/td>\n<td width=\"211\">Detection bias<\/td>\n<\/tr>\n<tr>\n<td width=\"120\">Data analyst<\/td>\n<td width=\"293\">Model and subgroup choices drift toward the favored arm.<\/td>\n<td width=\"211\">Analysis bias<\/td>\n<\/tr>\n<tr>\n<td width=\"120\">Monitoring committee<\/td>\n<td width=\"293\">Early impressions can influence stopping decisions; note that this group is often unblinded by design for safety.<\/td>\n<td width=\"211\">Interim decision bias<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Blinding_in_Peer_Review\"><\/span>Blinding in Peer Review<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><a href=\"https:\/\/www.editage.com\/blog\/peer-review-definition-types-process-timelines\/\">Peer review<\/a> borrows the same vocabulary for a different purpose. Here, blinding hides identities rather than treatment arms, so that manuscripts are judged on content rather than on the reputation, affiliation, gender, or nationality of the author.<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"156\"><strong>Model<\/strong><\/td>\n<td width=\"156\"><strong>Reviewer knows author?<\/strong><\/td>\n<td width=\"156\"><strong>Author knows reviewer?<\/strong><\/td>\n<td width=\"156\"><strong>Editor knows author?<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"156\">Open peer review<\/td>\n<td width=\"156\">Yes<\/td>\n<td width=\"156\">Yes<\/td>\n<td width=\"156\">Yes<\/td>\n<\/tr>\n<tr>\n<td width=\"156\">Single-blind<\/td>\n<td width=\"156\">Yes<\/td>\n<td width=\"156\">No<\/td>\n<td width=\"156\">Yes<\/td>\n<\/tr>\n<tr>\n<td width=\"156\">Double-blind<\/td>\n<td width=\"156\">No<\/td>\n<td width=\"156\">No<\/td>\n<td width=\"156\">Yes<\/td>\n<\/tr>\n<tr>\n<td width=\"156\">Triple-blind<\/td>\n<td width=\"156\">No<\/td>\n<td width=\"156\">No<\/td>\n<td width=\"156\">No<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Does_Double-Blind_Peer_Review_Work\"><\/span>Does Double-Blind Peer Review Work?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Only partly. Anonymization improves fairness signals in several studies, yet reviewers correctly guess author identity in a substantial share of manuscripts, especially in small or specialized fields.<\/p>\n<ul>\n<li>Guessing rates rise when the manuscript cites an unusual dataset, method, or long chain of self-citation.<\/li>\n<li>Preprint servers and conference talks routinely reveal authorship before review is finished.<\/li>\n<li>Many journals now offer a choice of models, and some publish reviewer reports alongside the accepted article.<\/li>\n<li>The practical takeaway: treat double-blind review as bias reduction, not bias elimination.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Limitations_and_Risks_of_Blinding\"><\/span>Limitations and Risks of Blinding<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Blinding is powerful but fragile. Recognizing where it fails is part of designing and appraising a study honestly.<\/p>\n<ul>\n<li>Feasibility: surgery, exercise, counseling, and most device studies cannot hide the intervention from the person delivering it.<\/li>\n<li>Side effects: a distinctive taste, flushing, drowsiness, or laboratory change can reveal the arm within days.<\/li>\n<li>Cost and complexity: matched placebos, coded packaging, and independent committees raise budgets and timelines.<\/li>\n<li>Safety: clinicians need a rapid emergency unblinding path, and each code break weakens the design.<\/li>\n<li>Ethics: participants must still give <a href=\"https:\/\/www.editage.com\/blog\/informed-consent-and-irb-approval-a-practical-guide-for-researchers\/\">informed consent<\/a> and must know that they may receive a placebo.<\/li>\n<li>Terminology: the words double-blind and triple-blind carry different meanings across journals and specialties.<\/li>\n<li>Cultural note: some guidance now prefers masking, because blinding is confusing in vision research and in studies involving blind participants.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Testing_Whether_Blinding_Worked\"><\/span>Testing Whether Blinding Worked<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ask participants and staff to guess their assignment at the end of the study, then compare the guesses with chance using a blinding index such as the <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0197245603001776\">Bang index<\/a> or the <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/(SICI)1097-0258(19960715)15:13%3C1421::AID-SIM266%3E3.0.CO;2-H\">James index<\/a>.<\/p>\n<ul>\n<li>Collect guesses before the results are announced, ideally at the final visit.<\/li>\n<li>Record the reason for each guess: side effects, symptom change, or pure speculation.<\/li>\n<li>Report the index by arm, since success often differs between the intervention\/<a href=\"https:\/\/www.editage.com\/blog\/experimental-group-definition-examples\/\">experimental group<\/a> and the <a href=\"https:\/\/www.editage.com\/blog\/control-group\/\">control group<\/a>.<\/li>\n<li>Interpret carefully: a correct guess may reflect a real treatment benefit rather than a broken blind.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"How_Should_Blinding_Be_Reported\"><\/span>How Should Blinding Be Reported?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Report exactly who was blinded, how, and whether the blind held. CONSORT asks trials to state which parties were masked and how the arms were made similar, rather than only naming a level.<\/p>\n<ul>\n<li>Name the masked roles: participants, care providers, investigators, assessors, analysts.<\/li>\n<li>Describe the mechanism: matched placebo, double-dummy, coded kits, central randomization, sham device.<\/li>\n<li>State who held the code and how emergency unblinding was handled.<\/li>\n<li>Report the number of code breaks and the reason for each.<\/li>\n<li>Report any blinding success assessment and its result.<\/li>\n<li>If the study was open-label, say so plainly and explain what protected the outcome assessment.<\/li>\n<li>Avoid the bare phrase double-blind with no further detail: readers cannot verify what it means.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Frequently_Asked_Questions\"><\/span>Frequently Asked Questions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_the_Difference_Between_Single-Blind_and_Double-Blind_Studies\"><\/span>What Is the Difference Between Single-Blind and Double-Blind Studies?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>In a single-blind study, only the participants are unaware of their assignment. In a double-blind study, both the participants and the investigators are unaware, which removes clinician expectation as well.<\/p>\n<ul>\n<li>Single-blind fits interventions that staff must obviously see, such as exercise programs.<\/li>\n<li>Double-blind fits interventions that can be matched, such as tablets, capsules, or injections.<\/li>\n<li>Double-blind designs carry lower risk of bias and are usually required for regulatory approval.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_the_Difference_Between_Blinding_and_Randomization\"><\/span>What Is the Difference Between Blinding and Randomization?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Randomization decides who is assigned to each group; blinding decides who is allowed to know that assignment. Randomization balances the groups at baseline, and blinding keeps them comparable afterward.<\/p>\n<ul>\n<li>A study can be randomized without being blinded, as in most surgical trials.<\/li>\n<li>A study can be blinded without being randomized, as in some blinded taste panels.<\/li>\n<li>Strong trials use both, plus allocation concealment at the moment of enrollment.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Can_a_Study_Be_Double-Blind_Without_a_Placebo\"><\/span>Can a Study Be Double-Blind Without a Placebo?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Yes. A double-blind trial can compare 2 active treatments that are made to look identical, or it can use a double-dummy design so that 2 different delivery routes remain indistinguishable.<\/p>\n<ul>\n<li>Example: 2 antibiotics supplied as identical capsules in coded bottles.<\/li>\n<li>Example: an active tablet plus placebo inhaler compared with a placebo tablet plus active inhaler.<\/li>\n<li>Placebos are common in double-blind trials, but they are a tool, not a definition.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_Is_a_Triple-Blind_Study_in_Psychology\"><\/span>What Is a Triple-Blind Study in Psychology?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>In psychology, a triple-blind study usually means the participants, the experimenters running the sessions, and the people scoring or analyzing the data are all unaware of condition assignment.<\/p>\n<ul>\n<li>Coders rate recordings or transcripts with condition labels stripped out.<\/li>\n<li>Experimenters follow scripted protocols to limit unintentional cues.<\/li>\n<li>Analysts work with coded conditions until the analysis plan is locked.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Why_Is_Blinding_Not_Possible_in_Surgical_Trials\"><\/span>Why Is Blinding Not Possible in Surgical Trials?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Surgeons must see what they are doing, so they cannot be blinded to the procedure. Patients can sometimes be blinded with a sham incision, but that raises ethical concerns about risk without benefit.<\/p>\n<ul>\n<li>Practical fix: blind the outcome assessor, the radiologist, and the statistician.<\/li>\n<li>Practical fix: use objective endpoints that leave little room for interpretation.<\/li>\n<li>Sham-controlled surgery exists but requires strong justification and careful ethics review.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_Does_Open-Label_Mean_in_a_Clinical_Trial\"><\/span>What Does Open-Label Mean in a Clinical Trial?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Open-label means nobody is blinded: participants, clinicians, and investigators all know which treatment was assigned. The design is common in early-phase, safety, and long-term extension studies.<\/p>\n<ul>\n<li>Open-label extensions often follow a blinded phase so every participant can access the active drug.<\/li>\n<li>Open-label results are more vulnerable to bias in subjective outcomes.<\/li>\n<li>Blinded outcome assessment can still be added to an open-label trial, a design often called PROBE.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Is_Double-Blind_Peer_Review_Better_Than_Single-Blind_Peer_Review\"><\/span>Is Double-Blind Peer Review Better Than Single-Blind Peer Review?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Double-blind review reduces bias linked to author name, gender, seniority, and institution, so many researchers prefer it. It is not clearly better on every measure, because anonymization often fails in practice.<\/p>\n<ul>\n<li>Double-blind helps most in fields with large status gaps between authors.<\/li>\n<li>Single-blind lets reviewers check track records, conflicts, and possible duplicate publication.<\/li>\n<li>Many journals now let authors choose the model at submission.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"How_Do_You_Blind_a_Manuscript_for_Double-Blind_Review\"><\/span>How Do You Blind a Manuscript for Double-Blind Review?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Remove every identifying detail from the manuscript and the file properties: author names, affiliations, emails, funding numbers, acknowledgments, ethics approval IDs, and any link to a named repository.<\/p>\n<ul>\n<li>Cite your own earlier work in the 3rd person, not as \u201cour previous study\u201d.<\/li>\n<li>Clear author metadata from the document properties before uploading.<\/li>\n<li>Move identifying details into the <a href=\"https:\/\/www.editage.com\/blog\/how-to-write-a-cover-letter-for-journal-submission-templates-examples-sample-disclosures\/\">cover letter<\/a> or the submission form, where only the editor sees them.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Glossary\"><\/span>Glossary<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"167\"><strong>Term<\/strong><\/td>\n<td width=\"457\"><strong>Definition<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"167\">Blinding (masking)<\/td>\n<td width=\"457\">Withholding information about group assignment from 1 or more parties involved in a study.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Allocation concealment<\/td>\n<td width=\"457\">Hiding the next upcoming assignment from the person enrolling participants, so recruitment cannot be manipulated.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Randomization<\/td>\n<td width=\"457\">Assigning participants to groups by chance, which makes the groups comparable at baseline.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Placebo<\/td>\n<td width=\"457\">An inactive pill, liquid, or injection made to look, taste, and feel like the active intervention.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Sham procedure<\/td>\n<td width=\"457\">A mock device, injection, or surgical step used as a control when a pill placebo is not possible.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Double-dummy<\/td>\n<td width=\"457\">A design in which every participant receives both an active form and a placebo form, so that 2 different formats stay indistinguishable.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Active placebo<\/td>\n<td width=\"457\">A control that reproduces a noticeable side effect of the study drug, making the arms harder to tell apart.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Outcome assessor<\/td>\n<td width=\"457\">The person who measures, scores, or adjudicates the study endpoint.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Unblinding (code break)<\/td>\n<td width=\"457\">Revealing an assignment, either accidentally or deliberately for a safety reason.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Performance bias<\/td>\n<td width=\"457\">Systematic differences in care or behavior that appear once people know the assignment.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Detection bias<\/td>\n<td width=\"457\">Systematic differences in how outcomes are measured, interpreted, or recorded between groups.<\/td>\n<\/tr>\n<tr>\n<td width=\"167\">Blinding index<\/td>\n<td width=\"457\">A statistic, such as the Bang index or James index, that tests whether guessing beat chance.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"References\"><\/span>References<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol>\n<li>Devereaux PJ, et al. Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials. doi:10.1001\/jama.285.15.2000<\/li>\n<li>Schulz KF, Grimes DA. Blinding in randomised trials: hiding who got what. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(02)07816-9\">https:\/\/doi.org\/10.1016\/S0140-6736(02)07816-9<\/a><\/li>\n<li>Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. doi:10.1136\/bmj.c332<\/li>\n<li>Tomkins A, Zhang M, Heavlin WD. Reviewer bias in single- versus double-blind peer review. <a href=\"https:\/\/doi.org\/10.1073\/pnas.1707323114\">https:\/\/doi.org\/10.1073\/pnas.1707323114<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"Blinding, also called masking, hides group assignment from 1 or more parties in a study so that expectations cannot distort behavior, measurement, or judgment. Single-blinding conceals allocation from participants; double-blinding also conceals it from investigators; triple-blinding extends concealment to a 3rd party such as outcome assessors, data analysts, or the monitoring committee. Blinding also governs [&hellip;]","protected":false},"author":3,"featured_media":2206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_ayudawp_aiss_exclude":false,"_ayudawp_aiss_summary":"Single-blinding conceals allocation from participants; double-blinding also conceals it from investigators; triple-blinding extends concealment to a 3rd party such as outcome assessors, data analysts, or the monitoring committee. Blinding also governs peer review, where single-blind, double-blind, and triple-blind models control different combinations of author, reviewer, and editor bias. Blinding is not the same as randomization: randomization decides who goes where, while blinding decides who is allowed to know.","_ayudawp_aiss_summary_provider":"extractive","_ayudawp_aiss_summary_hash":"a805ec8fe02fcc99356150fe41dd2ad56c198423"},"categories":[14],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Blinding in Research: Types, Examples, and Best Practices - Educational Articles For Researchers, Students And Authors - Editage Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.editage.com\/blog\/blinding-in-research-types-examples-and-best-practices\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blinding in Research: Types, Examples, and Best Practices - Educational Articles For Researchers, Students And Authors - Editage Blog\" \/>\n<meta property=\"og:description\" content=\"Blinding, also called masking, hides group assignment from 1 or more parties in a study so that expectations cannot distort behavior, measurement, or judgment. Single-blinding conceals allocation from participants; double-blinding also conceals it from investigators; triple-blinding extends concealment to a 3rd party such as outcome assessors, data analysts, or the monitoring committee. 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