{"id":1458,"date":"2016-01-15T15:52:33","date_gmt":"2016-01-15T15:52:33","guid":{"rendered":"https:\/\/www.editage.com\/insights\/two-research-teams-in-a-legal-battle-over-crispr-patent-ownership\/"},"modified":"2025-02-25T07:51:05","modified_gmt":"2025-02-25T07:51:05","slug":"two-research-teams-in-a-legal-battle-over-crispr-patent-ownership","status":"publish","type":"post","link":"https:\/\/www.editage.com\/insights\/two-research-teams-in-a-legal-battle-over-crispr-patent-ownership","title":{"rendered":"Two research teams in a legal battle over CRISPR patent ownership"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">A fierce legal battle has ensued between two research groups over the patenting rights of the CRISPR-Cas9 gene-editing technique. CRISPR, short for \u2018clustered regularly-interspaced short palindromic repeats,\u2019 was hailed as <a href=\"http:\/\/www.sciencemag.org\/topic\/2015-breakthrough-year\">one of the biggest breakthroughs of 2014<\/a> as it could likely rid humans of deadly diseases and help in growing organs in labs, among many other applications.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">Jennifer Doudna of the University of California, Berkeley; and Emmanuelle Charpentier, of the Helmholtz Centre for Infection Research, have both applied for a patent over the use of CRISPR technology in mammalian cells. However, the U.S. Patent and Trademark Office (USPTO) declared that <a href=\"https:\/\/acts.uspto.gov\/ifiling\/PDFfromDocumentum?No=106048&amp;docTy=NOTICE+TO+DECLARE+INTERFERENCE&amp;action=getContentByDocType\">these patents interfere with those granted to Feng Zhang<\/a>, a scientist at the Broad Institute in Cambridge, who already owns around 12 patents that detail the use of CRISPR.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">The legal dispute mainly arose because Doudna and Charpentier, who were affiliated to the University of California when filing their patent application in March 2013, whereas Zhang filed his application in October 2013. However, under a special expedited review program requested by Zhang\u2019s institution, he was granted the patent in April 2014 before the original application by Doudna and Charpentier was considered. Therefore, the University of California requested the USPTO to review the patent and begin an interference proceeding so that the actual inventors of the technique are justly granted the patent.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">Previously, USPTO honored the first inventor with a patent. However, the rule has changed after 2013 and now patents are awarded to those who apply first. Since Doudna and Charpentier filed for patents before the change in the law, it is possible that the older rule may be considered in their case. Patent disputes among institutions are not uncommon but they are rarely as intense as the one in question. Arti Rai, a legal scholar at Duke University in Durham, says, \u201c<a href=\"http:\/\/www.nature.com\/news\/bitter-fight-over-crispr-patent-heats-up-1.17961\">This seems more bitter than disputes I\u2019ve heard of in the past.<\/a>\u201d<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">A lot rests on the outcome of this legal proceeding. Whoever wins the patent would benefit monetarily: any company that hopes to use the technology commercially would have to acquire license patents from the winning party. In fact, many companies have emerged that want to use the CRISPR technique and have been raising a decent amount of money from investors who think the technology could be used commercially to develop new treatments. For instance, Editas Medicine, a Cambridge-based startup company that is interested in the CRISPR technique, recently declared that it has planned <a href=\"https:\/\/www.washingtonpost.com\/news\/wonk\/wp\/2016\/01\/13\/control-of-crispr-biotechs-most-promising-breakthrough-is-up-for-grabs\/\">a $100 million initial public offering<\/a>. \u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">The USPTO has termed Doudna as the \u201csenior party\u201d and Zhang as the \u201cjunior party,\u201d suggesting that prima facie Doudna seems to be the first inventor of CRISPR. However, for a fair decision, both the parties will have to provide adequate evidence to prove that they were the first ones to invent the technique.\u00a0 USPTO has appointed a panel of three expert judges who form the Board of Patent Appeals and Interferences to determine which party should rightfully own the patent.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\">On a positive note, both the institutions have made the technology free for use for basic research and intend to continue doing so. It remains to be seen who ultimately emerges with the patent. \u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\"><strong>References:<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\"><a href=\"http:\/\/www.nature.com\/news\/bitter-fight-over-crispr-patent-heats-up-1.17961\"><em>Bitter fight over CRISPR patent heats up<\/em><\/a><em> (accessed January 15)<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\"><a href=\"https:\/\/www.washingtonpost.com\/news\/wonk\/wp\/2016\/01\/13\/control-of-crispr-biotechs-most-promising-breakthrough-is-up-for-grabs\/\"><em>Control of CRISPR, biotech\u2019s most promising breakthrough, is in dispute<\/em><\/a><em> (accessed January 15)<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:14px;\"><a href=\"http:\/\/www.technologyreview.com\/view\/545411\/crispr-dispute-to-be-decided-by-patent-office\/\"><em>CRISPR Dispute to Be Decided by Patent Office<\/em><\/a><em> (accessed January 15)<\/em><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A fierce legal battle has ensued between two research groups over the patenting rights of the CRISPR-Cas9 gene-editing technique. CRISPR, short for \u2018clustered regularly-interspaced short palindromic repeats,\u2019 was hailed as one of the biggest breakthroughs of 2014 as it could likely rid humans of deadly diseases and help in growing organs in labs, among many [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":33313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2408],"tags":[2644],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-1458","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news","tag-industry-updates"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Two research teams in a legal battle over CRISPR patent ownership | Editage Insights<\/title>\n<meta name=\"description\" content=\"A 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