{"id":1710,"date":"2015-03-31T07:24:49","date_gmt":"2015-03-31T07:24:49","guid":{"rendered":"https:\/\/www.editage.com\/insights\/geneticists-debate-dna-editing-in-human-embryos\/"},"modified":"2025-02-25T06:27:51","modified_gmt":"2025-02-25T06:27:51","slug":"geneticists-debate-dna-editing-in-human-embryos","status":"publish","type":"post","link":"https:\/\/www.editage.com\/insights\/geneticists-debate-dna-editing-in-human-embryos","title":{"rendered":"Geneticists debate DNA editing in human embryos"},"content":{"rendered":"<p align=\"center\"><em>\u201cWe are humans, not transgenic rats.\u201d<\/em><\/p>\n<p align=\"center\"><em>Edward Lanphier, president of Sangamo and chairman of the Alliance for Regenerative Medicine in Washington DC<\/em><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">Should germline modification \u2013 a gene-editing technique \u2013 be allowed on human embryos? This ethically laced question has generated much hype and discussion among geneticists. On March 5, <em>MIT Technology Review<\/em> <a href=\"http:\/\/www.technologyreview.com\/featuredstory\/535661\/engineering-the-perfect-baby\/\">reported<\/a> that studies using genome-editing tools, such as CRISPR\/Cas9 and zinc-finger nucleases, to make changes to the human embryo\u2019s DNA are about to be published. Such genetic modifications to the embryos would be passed on to the future generations; therefore, some researchers opine that this is an ethical line that should not be crossed. \u00a0<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">Following the article in <em>MIT Technology Review<\/em>, Edward Lanphier and his colleagues who are involved in the study of genome-editing techniques in somatic (non-reproductive) cells, wrote a <a href=\"http:\/\/www.nature.com\/news\/don-t-edit-the-human-germ-line-1.17111\">comment article<\/a> in <em>Nature<\/em>. They appealed to scientists to refrain from modifying human embryos, even in research, since <a href=\"https:\/\/www.kolabtree.com\/find-an-expert\/subject\/genetics-and-genomics\">genome editing<\/a> in human embryos with the use of current technologies &#8220;could have unpredictable effects on future generations\u201d and that such work can be misused for \u201cnon-therapeutic modifications\u201d such as creating a genetically modified baby with \u2018perfect blue eyes.\u2019 Moreover, they also warn that such an \u201cethical breach\u201d could possibly <a href=\"http:\/\/www.nature.com\/news\/ethics-of-embryo-editing-divides-scientists-1.17131\">jeopardize the use of gene editing even in non-reproductive cells<\/a>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">While some researchers are completely against germline editing, others such as Nobel laureate geneticist Craig Mello of the University of Massachusetts, Worcester, are in support of germline editing as it could offer humans protection from life-threatening diseases such as cancer and HIV. George Church, a geneticist at Harvard Medical School in Boston, Massachusetts, feels that modification of human embryos should be banned only till \u201csafety issues are cleared up and there is general consensus that it is OK.\u201d Church remarks that gene editing should be closely monitored in animals before it is practiced on humans, as this would address the concern some researchers have raised regarding unintended introduction of mutations at locations other than those targeted.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">Dana Carroll, a geneticist at the University of Utah in Salt Lake City <a href=\"http:\/\/www.nature.com\/news\/ethics-of-embryo-editing-divides-scientists-1.17131\">suggests<\/a>\u00a0<\/span><\/span><span style=\"font-size: 14px; font-family: verdana, geneva, sans-serif;\">a way of resolving this ethical issue. She thinks<\/span><span style=\"font-size: 14px; font-family: verdana, geneva, sans-serif;\">\u00a0a national agency, such as the US National Academy of Sciences, that includes medical professionals and interested public, should be organized to weigh up the positive and negative aspects of germline editing.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">It remains to be seen whether the study on germline modification gets published and the research gets a legal nod. What are your thoughts on this issue? Please share your views.\u00a0<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cWe are humans, not transgenic rats.\u201d Edward Lanphier, president of Sangamo and chairman of the Alliance for Regenerative Medicine in Washington DC Should germline modification \u2013 a gene-editing technique \u2013 be allowed on human embryos? This ethically laced question has generated much hype and discussion among geneticists. On March 5, MIT Technology Review reported that [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":33313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2408],"tags":[2644],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-1710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news","tag-industry-updates"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Geneticists debate DNA editing in human embryos | Editage Insights<\/title>\n<meta name=\"description\" content=\"Should germline modification \u2013 a gene-editing technique \u2013 be allowed on human embryos? 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