{"id":3267,"date":"2019-12-24T06:49:18","date_gmt":"2019-12-24T06:49:18","guid":{"rendered":"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\/"},"modified":"2025-01-15T06:31:08","modified_gmt":"2025-01-15T06:31:08","slug":"solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder","status":"publish","type":"post","link":"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder","title":{"rendered":"Solving the puzzle of IgG4-related disease, the elusive autoimmune disorder"},"content":{"rendered":"<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, mistaking the self-cells for invading disease-causing cells. Often, the cause for this spontaneous dysfunction is not clear, and hence, treatment of these diseases presents a major and ongoing challenge. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">One recently discovered autoimmune disease is the IgG4-related disease (or IgG4-RD), which involves the infiltration of plasma cells that are specific to the immunoglobulin (antibody) IgG4 into the body tissue, resulting in irreversible tissue damage in multiple organs. In most patients with IgG4-RD, the blood levels of IgG4 also tend to be higher than those in healthy individuals. Previous studies show that T cells\u2014which are white blood cells charged with duties of the immune response\u2014play a key role in the disease mechanism. In particular, special T cells called cytotoxic T lymphocytes, or CTLs, were found in abundance from the inflamed or affected pancreas of patients, along with IgG4. But what was the exact role of CTLs?<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><iframe allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\" frameborder=\"0\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/tfiKH5Dl2eA\" width=\"560\"><\/iframe> <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">In a new <span class=\"MsoHyperlink\" style=\"color:#0563c1\"><span style=\"text-decoration:underline\"><a href=\"https:\/\/academic.oup.com\/intimm\/advance-article-abstract\/doi\/10.1093\/intimm\/dxz073\/5622784?redirectedFrom=fulltext\" style=\"color:#0563c1; text-decoration:underline\">study published in <i>International Immunology<\/i><\/a><\/span><\/span>, a team of scientists from Tokyo University of Science decided to find the answer to this question. Prof. Masato Kubo, a member of this team, states that their aim was twofold. \u201cWe planned to explore how IgG4 Abs contributes to the CTL-mediated pancreas tissue damage in IgG4-RD, and also to evaluate the pathogenic function of human IgG4 Abs using the mouse model that we have established.\u201d The latter is especially important, as IgG4 is not naturally present in mice, meaning that there is a severe lack of adequate animal models to explore this disease.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">With these aims, they selected mice that have been genetically programmed to express a protein called ovalbumin (the major protein in egg white) in their pancreas. Then, they injected IgG4 that specifically targets ovalbumin into the mice. Their assumption was that IgG4 would target the pancreas and bring about IgG4-RD-like symptoms. However, what they found was surprising. No inflammation or any other symptom typical of IgG4-RD appeared. This convinced the researchers that IgG4 alone was not the causative factor of IgG4-RD.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Next, to check if it was the CTLs that were perhaps the villain of the story, the scientists injected both IgG4 specific against ovalbumin as well as CTLs. Now, the pancreas of the mice showed tissue damage and inflammation. Thus, it was established that the presence of CTLs and IgG4 was necessary for pancreatic inflammation.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">When they probed further, they found that another variation of T cells, known as T follicular helper or \u201cT<sub>FH<\/sub> cells,\u201d which develop from the natural T cells of the mice, produce self-reactive antibodies like IgG4, which induce inflammation in combination with CTLs.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Once the puzzle was pieced together, the scientists now had the opportunity to zero in on the target step for intervention; after all, if one of these steps is disrupted, the inflammation can be prevented. After much deliberation, they propose that Janus kinase, or JAK, can be a suitable target. JAK is a key component of the JAK-STAT cellular signaling pathway, and this pathway is an integral step in the conversion of natural T cells of the mice to T<sub>FH<\/sub><sup><\/sup>cells. If this JAK is inhibited, this conversion will not take place, meaning that even the presence of CTLs will not be able to induce inflammation. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Prof. Kubo also suggests a broader outlook, not limited to the therapeutic option explored in the study. He states, \u201cbased on our findings, the therapeutic targets for IgG4-related diseases can be the reduction of T<sub>FH<\/sub> cell responses and the auto-antigen specific CTL responses. These can also provide the fundamental basis for developing new therapeutic applications.\u201d<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">These proposed therapeutic targets need further exploration, but once developed, they have the potential to improve the lives of millions of patients with IgG4-RD worldwide. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><b><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Reference<\/span><\/b><\/span><\/span><\/p>\n<table class=\"Table\" style=\"border-collapse:collapse; border:undefined\">\n<tbody>\n<tr>\n<td style=\"width:130.5pt; padding:0in 0in 0in 0in\" valign=\"top\" width=\"174\">\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-size:11.0pt\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Title of original paper:<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-size:11.0pt\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Journal:<\/span><\/span><\/span><\/span><\/p>\n<\/td>\n<td style=\"width:320.8pt; padding:0in 0in 0in 0in\" valign=\"top\" width=\"428\">\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-size:11.0pt\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Synergistic effect of IgG4 antibody and CTLs causes tissue inflammation in IgG4-related disease<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><i><span style=\"font-size:11.0pt\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">International Immunology<\/span><\/span><\/i><\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width:130.5pt; padding:0in 0in 0in 0in\" valign=\"top\" width=\"174\">\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-size:11.0pt\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">DOI:<\/span><\/span><\/span><\/span><\/p>\n<\/td>\n<td style=\"width:320.8pt; padding:0in 0in 0in 0in\" valign=\"top\" width=\"428\">\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span class=\"MsoHyperlink\" style=\"color:#0563c1\"><span style=\"text-decoration:underline\"><span style=\"font-size:11.0pt\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><a href=\"https:\/\/doi.org\/10.1093\/intimm\/dxz073\" style=\"color:#0563c1; text-decoration:underline\">https:\/\/doi.org\/10.1093\/intimm\/dxz073<\/a><\/span><\/span><\/span><\/span>\u00a0 <\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:Calibri,sans-serif\"><span style=\"color:black\"><b>About <\/b><b>The Tokyo University of Science<\/b><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><a href=\"https:\/\/www.tus.ac.jp\/en\/mediarelations\/\">Tokyo University of Science<\/a> (TUS) is a well-known and respected university, and the largest science-specialized private research university in Japan, with four campuses in central Tokyo and its suburbs and in Hokkaido. Established in 1881, the university has continually contributed to Japan&#8217;s development in science through inculcating the love for science in researchers, technicians, and educators. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\">\u00a0<\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">With a mission of \u201cCreating science and technology for the harmonious development of nature, human beings, and society&#8221;, TUS has undertaken a wide range of research from basic to applied science. TUS has embraced a multidisciplinary approach to research and undertaken intensive study in some of today&#8217;s most vital fields. TUS is a meritocracy where the best in science is recognized and nurtured. It is the only private university in Japan that has produced a Nobel Prize winner and the only private university in Asia to produce Nobel Prize winners within the natural sciences field. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:Calibri,sans-serif\"><span style=\"color:black\"><b>About Professor Masato Kubo from Tokyo University of Science<\/b><\/span><\/span><\/span><\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:Calibri,sans-serif\"><span style=\"color:black\">Dr Masato Kubo is a Professor at the Tokyo University of Science. A respected and senior researcher in his field, he has more than 226 publications to his credit. He is also the corresponding author of this study. His research interests include Immunology and Allergology. He is the team leader at the Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences.<\/span><\/span><\/span><\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:Calibri,sans-serif\"><span style=\"color:black\"><b>Funding information<\/b><\/span><\/span><\/span><\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:Calibri,sans-serif\"><span style=\"color:black\">This study was supported by grants from JSPS KAKENHI (grant no. 19H03491), Japan Agency for Medical Research and Development (AMED), AMED-CREST, and Toppan Printing CO., LTD.<\/span><\/span><\/span><\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p class=\"Default\" style=\"margin:0in 0in 0.0001pt\"><strong><span style=\"font-size:12pt\"><span style=\"font-family:Calibri,sans-serif\"><span style=\"color:black\">Media contact\u00a0<\/span><\/span><\/span><\/strong><\/p>\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span lang=\"EN-GB\" style=\"font-size:11.0pt\" xml:lang=\"EN-GB\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Tsutomu Shimizu <\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span lang=\"EN-GB\" style=\"font-size:11.0pt\" xml:lang=\"EN-GB\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Email: <span class=\"MsoHyperlink\" style=\"color:#0563c1\"><span style=\"text-decoration:underline\"><a href=\"mailto:mediaoffice@admin.tus.ac.jp\" style=\"color:#0563c1; text-decoration:underline\">mediaoffice@admin.tus.ac.jp<\/a><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, mistaking the self-cells for invading disease-causing cells. Often, the cause for this spontaneous dysfunction is not clear, and hence, treatment of these diseases presents [&hellip;]<\/p>\n","protected":false},"author":1152,"featured_media":33313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2435],"tags":[2482],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-3267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-trending-research","tag-science-update"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Solving the puzzle of the autoimmune IgG4-related disease | Editage Insights<\/title>\n<meta name=\"description\" content=\"IgG4-related autoimmune disease has no known cure. Previous research indicates that T cells and the immunoglobulin IgG4 are key causative factors. Scientists from Tokyo University of Science have explored new targets for therapy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Solving the puzzle of the autoimmune IgG4-related disease | Editage Insights\" \/>\n<meta property=\"og:description\" content=\"IgG4-related autoimmune disease has no known cure. Previous research indicates that T cells and the immunoglobulin IgG4 are key causative factors. Scientists from Tokyo University of Science have explored new targets for therapy.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\" \/>\n<meta property=\"og:site_name\" content=\"Editage Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Editage\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-24T06:49:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-15T06:31:08+00:00\" \/>\n<meta name=\"author\" content=\"Impact Science\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Editage\" \/>\n<meta name=\"twitter:site\" content=\"@Editage\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Impact Science\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\"},\"author\":{\"name\":\"Impact Science\",\"@id\":\"https:\/\/www.editage.com\/insights\/#\/schema\/person\/cbcaf87b3854025dbc992cc0df30714d\"},\"headline\":\"Solving the puzzle of IgG4-related disease, the elusive autoimmune disorder\",\"datePublished\":\"2019-12-24T06:49:18+00:00\",\"dateModified\":\"2025-01-15T06:31:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\"},\"wordCount\":958,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.editage.com\/insights\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp\",\"keywords\":[\"Science Update\"],\"articleSection\":[\"Trending Research\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\",\"url\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder\",\"name\":\"Solving the puzzle of the autoimmune IgG4-related disease | Editage Insights\",\"isPartOf\":{\"@id\":\"https:\/\/www.editage.com\/insights\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.editage.com\/insights\/solving-the-puzzle-of-igg4-related-disease-the-elusive-autoimmune-disorder#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp\",\"datePublished\":\"2019-12-24T06:49:18+00:00\",\"dateModified\":\"2025-01-15T06:31:08+00:00\",\"description\":\"IgG4-related autoimmune disease has no known cure. 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