{"id":3450,"date":"2020-04-23T09:24:32","date_gmt":"2020-04-23T09:24:32","guid":{"rendered":"https:\/\/www.editage.com\/insights\/novel-reversible-technique-produces-acyl-fluoride-using-rare-metal\/"},"modified":"2025-01-15T06:30:12","modified_gmt":"2025-01-15T06:30:12","slug":"novel-reversible-technique-produces-acyl-fluoride-using-rare-metal","status":"publish","type":"post","link":"https:\/\/www.editage.com\/insights\/novel-reversible-technique-produces-acyl-fluoride-using-rare-metal","title":{"rendered":"Novel reversible technique produces acyl fluoride using rare metal"},"content":{"rendered":"<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">In organic chemistry, metals have recently gained attention for their roles as catalysts of a variety of reactions where two different starting materials are joined together, generally known as cross-coupling reactions. Acyl fluorides are a special type of carbon compounds that contain fluorine in their structure. They are very important in various cross-coupling reactions due to their stability and reactivity, as evidenced by the increasing amount of research reporting their relevance.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Because of their central role in these reactions, synthesis of acyl fluorides is an important research topic explored by chemists worldwide. <\/span><\/span><\/span><\/span><span lang=\"EN-US\" style=\"font-size:11.0pt\" xml:lang=\"EN-US\"><span style=\"line-height:115%\"><span style=\"font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;\">Scientists have already devised several techniques to synthesize acyl fluorides using metal catalysts, but using a simple acyl\u00a0<\/span><\/span><\/span><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">fluoride as a reagent for the synthesis of complex acyl fluorides is not explored. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Junior Assoc Prof Yohei Ogiwara, Prof Norio Sakai, and Shintaro Hosaka, a group of scientists from the Tokyo University of Science, had previously identified a variety of techniques to transform acyl fluorides using palladium as a catalyst, including a technique involving the manipulation of the acyl C\u2013F bond. As a result of detailed experiments, they found that palladium can help cleave the acyl C\u2013F bond of acyl fluoride. What was more fascinating was that this reaction was reversible, meaning that the presence of palladium also catalyzed the formation of this bond.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">These findings encouraged the scientists to now develop a novel strategy for the synthesis of acyl fluorides. &#8220;We envisioned\u00a0<\/span><\/span><\/span><\/span><span lang=\"EN-US\" style=\"font-size:11.0pt\" xml:lang=\"EN-US\"><span style=\"line-height:115%\"><span style=\"font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;\"><i>reversibility of the acyl C\u2212F bond cleavage\/formation may be the answer to the conundrum of acyl fluoride synthesis,<\/i>\u201d states Dr Ogiwara, lead scientist of the study. In their <\/span><\/span><\/span><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><a href=\"https:\/\/doi.org\/10.1021\/acs.organomet.0c00028\" style=\"color:blue; text-decoration:underline\">recent report published in <i>Organometallics<\/i><\/a><u><span style=\"color:#1155cc\">,<\/span><\/u> they detail the palladium\/phosphine-catalyzed synthesis of a variety of acyl fluorides from a simple and commercially available acyl fluoride\u2014called the benzoyl fluoride\u2014as a fluoride source.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">This novel method involves an \u201cacyl-exchange reaction,\u201d whereby a reaction is induced between benzoyl fluoride and benzoic anhydride by palladium. Benzoic anhydride is a part of a larger subclass of compounds known as acid anhydrides, which are composed of two acyl groups bonded to the same oxygen atom. Therefore, this compound was a perfect supplier of acyl groups.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">The researchers found that this reaction resulted in the production of adequate amounts of complex acyl fluorides as desired. By testing out various catalysts and substrates (the chemicals undergoing the reaction), they confirmed that benzoyl fluoride, benzoic anhydride, and palladium indeed provide the best results. However, the preferred complex acyl fluoride can be obtained by playing around with the substrates. This reaction is thus efficient and allows for the preparation of a variety of more complex acyl fluorides.\u00a0<\/span><\/span><\/span><\/span><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">\u201cAt its core,\u201d reports Prof Sakai, \u201cthis reaction proceeds through the cleavage and formation of the acyl C\u2212F bond at the palladium center.\u201d<\/span><\/span><\/span><\/span><\/p>\n<p><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Using this method, Dr Ogiwara and his team succeeded in obtaining 10 or more types of acyl fluoride from benzoyl fluoride, demonstrating the efficiency of this technique. An added bonus is that through this technique, acyl fluoride presents an attractive source of fluorine. \u201cThis study represents the first practical protocol to use\u00a0 commercially available acyl fluoride as a fluorination reagent for the catalytic generation of a variety of value-added acyl fluorides,\u201d reports Prof Sakai. The reversibility of the breaking and formation of the C\u2013F bond is the highlight of this study, and it could potentially find many industrial applications.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><b><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Reference<\/span><\/b><\/span><\/span><\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><span style=\"color:black\">Title of original paper: Benzoyl Fluorides as Fluorination Reagents: Reconstruction of Acyl Fluorides via Reversible Acyl C\u2212F Bond Cleavage\/Formation in Palladium Catalysis<\/span><\/span><\/span><\/span><\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><span style=\"color:black\">Journal: <i>Organometallics<\/i><\/span><\/span><\/span><\/span><\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><span style=\"color:black\">DOI: <a href=\"https:\/\/doi.org\/10.1021\/acs.organomet.0c00028\" style=\"color:blue; text-decoration:underline\">10.1021\/acs.organomet.0c00028<\/a><\/span><\/span><\/span><\/span><\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><b><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><span style=\"color:black\">About The Tokyo University of Science<\/span><\/span><\/b><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><a href=\"https:\/\/www.tus.ac.jp\/en\/mediarelations\/\">Tokyo University of Science <\/a>(TUS) is a well-known and respected university, and the largest science-specialized private research university in Japan, with four campuses in central Tokyo and its suburbs and in Hokkaido. Established in 1881, the university has continually contributed to Japan&#8217;s development in science through inculcating the love for science in researchers, technicians, and educators. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\">\u00a0<\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">With a mission of \u201cCreating science and technology for the harmonious development of nature, human beings, and society&#8221;, TUS has undertaken a wide range of research from basic to applied science. TUS has embraced a multidisciplinary approach to research and undertaken intensive study in some of today&#8217;s most vital fields. TUS is a meritocracy where the best in science is recognized and nurtured. It is the only private university in Japan that has produced a Nobel Prize winner and the only private university in Asia to produce Nobel Prize winners within the natural sciences field.\u00a0<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><b><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><span style=\"color:black\">About Dr <\/span><\/span><\/b><b><span style=\"background:white\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Yohei Ogiwara<\/span><\/span><\/b><b><span style=\"font-family:&quot;Calibri&quot;,sans-serif\"><span style=\"color:black\"> from Tokyo University of Science<\/span><\/span><\/b><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Dr Yohei Ogiwara is a Junior Associate Professor at the Department of Pure and Applied Chemistry, Tokyo University of Science. Having completed his doctoral studies in 2014 from Keio University, he went on to serve as an Assistant Professor at TUS before progressing to his current role. His key research interest is organic chemistry, with a focus on organometallic and synthetic chemistry. He is a recipient of many prestigious awards, most recently including the research grant from TOBE MAKI Scholarship Foundation in 2019. <\/span><\/span><\/span><\/span><\/p>\n<p style=\"border:none; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><b><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Media contact <\/span><\/b><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\">\u00a0<\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Tsutomu Shimizu <\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 0.0001pt\"><span style=\"font-size:12pt\"><span style=\"text-justify:inter-ideograph\"><span style=\"font-family:&quot;Times New Roman&quot;,serif\"><span style=\"font-family:&quot;Calibri&quot;,sans-serif\">Email: <a href=\"mailto:mediaoffice@admin.tus.ac.jp\" style=\"color:blue; text-decoration:underline\">mediaoffice@admin.tus.ac.jp<\/a><\/span><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In organic chemistry, metals have recently gained attention for their roles as catalysts of a variety of reactions where two different starting materials are joined together, generally known as cross-coupling reactions. Acyl fluorides are a special type of carbon compounds that contain fluorine in their structure. They are very important in various cross-coupling reactions due [&hellip;]<\/p>\n","protected":false},"author":1152,"featured_media":33313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2435],"tags":[2482],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-3450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-trending-research","tag-science-update"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Novel Reversible Technique Produces Acyl Fluoride using Rare Metal | Editage Insights<\/title>\n<meta name=\"description\" content=\"Researchers in Tokyo discover Novel Reversible Technique Produces Acyl Fluoride using Rare Metal\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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