{"id":4411,"date":"2023-10-25T08:03:18","date_gmt":"2023-10-25T08:03:18","guid":{"rendered":"https:\/\/www.editage.com\/insights\/unpacking-basket-trials-in-biomedical-research-a-how-to-guide\/"},"modified":"2025-01-15T06:16:28","modified_gmt":"2025-01-15T06:16:28","slug":"unpacking-basket-trials-in-biomedical-research-a-how-to-guide","status":"publish","type":"post","link":"https:\/\/www.editage.com\/insights\/unpacking-basket-trials-in-biomedical-research-a-how-to-guide","title":{"rendered":"Unpacking basket trials in biomedical research: A how-to guide\u00a0"},"content":{"rendered":"<p>Basket trials have emerged as a promising approach in biomedical research, offering a new approach to <a aria-label=\"Link clinical trials\" href=\"https:\/\/www.editage.com\/insights\/how-outcome-switching-is-rendering-clinical-trials-meaningless?refer=insights-search-posts\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/insights\/how-outcome-switching-is-rendering-clinical-trials-meaningless?refer=insights-search-posts\">clinical trials<\/a>. These trials are particularly intriguing because they challenge the traditional way in which biomedical studies are conducted. In this blog post, we\u2019ll explore what basket trials are, their significance, and the crucial considerations for statistical analysis within this innovative framework.\u00a0<\/p>\n<p><strong>What Are Basket Trials?<\/strong>\u00a0<\/p>\n<p>Basket trials are a type of clinical trial that diverges from the traditional one-size-fits-all approach. Instead of focusing on a single disease, basket trials include patients with different types of diseases or conditions, but who share a specific genetic alteration. In essence, it\u2019s like putting all your eggs in one basket \u2013 but in a scientific and strategic way.\u00a0<\/p>\n<p>Let\u2019s also take a look at umbrella trials and platform trials&#8212;two other approaches very similar to basket trials:\u00a0<\/p>\n<ul>\n<li>Umbrella Trials: Umbrella trials are clinical trials that investigate multiple sub-studies or treatment approaches within a single overarching trial. Patients are assigned to different sub-studies based on specific characteristics or biomarkers, allowing for the evaluation of various treatments simultaneously.\u00a0<\/li>\n<li>Platform Trials: Platform trials are adaptive clinical trial designs that continuously assess and compare multiple treatments for a specific disease. New treatments can be added, and ineffective ones removed as the trial progresses, streamlining the evaluation process.\u00a0<\/li>\n<\/ul>\n<p>Master protocols are comprehensive trial designs that enable the simultaneous evaluation of multiple treatments, disease subtypes, or biomarkers within a single framework. They offer flexibility in adapting to emerging data and can speed up drug development.\u00a0<\/p>\n<p>To learn more about basket, umbrella, and platform trials and how they fit under the master protocol framework, you can refer to <a aria-label=\"Link Park et al. (2020)\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32031692\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32031692\/\">Park et al. (2020)<\/a>\u2019s review.\u00a0\u00a0\u00a0<\/p>\n<p><strong>Benefits of Basket Trials<\/strong>\u00a0<\/p>\n<ol>\n<li>Precision Medicine: Basket trials align with the principles of precision medicine. By targeting specific genetic alterations, researchers can tailor treatments to the individual patient\u2019s needs, potentially improving outcomes. As shown by <a aria-label=\"Link Di Liello et al. (2021)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8618758\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8618758\/\">Di Liello et al. (2021)<\/a>, basket trials speed up screening and enrolment in precision oncology, especially when rare cancer groups are involved.\u00a0\u00a0<\/li>\n<li>Faster Drug Development: These trials can accelerate the drug development process. Instead of conducting separate trials for each disease, basket trials allow researchers to test multiple treatments concurrently, reducing time and costs. As <a aria-label=\"Link Cummings et al. (2022)\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35614479\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35614479\/\">Cummings et al. (2022)<\/a> point out, basket trials can increase drug development efficiency by reducing redundancies, boosting recruitment, and sharing placebo groups.\u00a0\u00a0<\/li>\n<li>Uncovering Rare Mutations: Basket trials provide a unique opportunity to study rare genetic mutations, which might otherwise be challenging to investigate due to their low prevalence in individual diseases. <a aria-label=\"Link Tao et al. (2018)\" href=\"https:\/\/www.annualreviews.org\/doi\/10.1146\/annurev-med-062016-050343\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.annualreviews.org\/doi\/10.1146\/annurev-med-062016-050343\">Tao et al. (2018)<\/a> argue that basket trials are most effective in assessing the efficacy of targeting genomic alterations that occur at low frequencies across a wide variety of tumor types.\u00a0<\/li>\n<\/ol>\n<p><strong>Statistical Considerations in Basket Trials<\/strong>\u00a0<\/p>\n<p>Now, let\u2019s delve into the statistical aspects that researchers need to consider when embarking on a basket trial journey.\u00a0<\/p>\n<p><i>Patient Selection and Stratification<\/i>\u00a0<\/p>\n<p>In basket trials, patient selection is paramount. Ensure that patients are stratified based on the specific genetic alteration under investigation. This stratification is critical for accurate statistical analysis and meaningful results.\u00a0<\/p>\n<p><i>Endpoints and Biomarkers<\/i>\u00a0<\/p>\n<p>Define clear endpoints and biomarkers that align with the trial\u2019s objectives. These should be relevant to the genetic alteration and the diseases being studied. A well-chosen endpoint is essential for <a aria-label=\"Link robust statistical analysis\" href=\"https:\/\/www.editage.com\/blog\/statistical-practices-to-generate-robust-research-data\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/blog\/statistical-practices-to-generate-robust-research-data\/\">robust statistical analysis<\/a>.\u00a0<\/p>\n<p><i>Sample Size and Power<\/i>\u00a0<\/p>\n<p>Determine an appropriate <a aria-label=\"Link sample size\" href=\"https:\/\/www.editage.com\/insights\/an-introduction-to-sample-size-effect-size-and-statistical-power-for-biomedical-researchers?refer=insights-search-posts\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/insights\/an-introduction-to-sample-size-effect-size-and-statistical-power-for-biomedical-researchers?refer=insights-search-posts\">sample size<\/a> for each basket. Since basket trials often involve smaller patient populations for each disease subtype, it\u2019s crucial to assess <a aria-label=\"Link statistical power\" href=\"https:\/\/www.editage.com\/insights\/importance-of-statistical-power-in-research-design?refer=insights-search-posts\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/insights\/importance-of-statistical-power-in-research-design?refer=insights-search-posts\">statistical power<\/a> carefully. Small sample sizes can lead to underpowered studies and unreliable results.\u00a0<\/p>\n<p><i>Adaptive Trial Design<\/i>\u00a0<\/p>\n<p>Consider using adaptive trial designs, such as <a aria-label=\"Link Bayesian methods\" href=\"https:\/\/www.editage.com\/insights\/unlocking-the-benefits-of-bayesian-adaptive-clinical-trial-design-for-medical-and-life-science-research?refer=insights-search-posts\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/insights\/unlocking-the-benefits-of-bayesian-adaptive-clinical-trial-design-for-medical-and-life-science-research?refer=insights-search-posts\">Bayesian methods<\/a> or group sequential designs. These allow for flexibility in adjusting the trial parameters based on accumulating data, which is often necessary in basket trials with evolving patient populations.\u00a0<\/p>\n<p><i>Data Analysis and Interpretation<\/i>\u00a0<\/p>\n<p>When analyzing the data, employ <a aria-label=\"Link statistical methods\" href=\"https:\/\/www.editage.com\/blog\/statistical-practices-to-generate-robust-research-data\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/blog\/statistical-practices-to-generate-robust-research-data\/\">statistical methods<\/a> suitable for the specific trial design. Be prepared for complex statistical challenges, such as <a aria-label=\"Link multiple hypothesis testing\" href=\"https:\/\/www.editage.com\/blog\/hypothesis-testing-different-types-for-biomedical-researchers\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/blog\/hypothesis-testing-different-types-for-biomedical-researchers\/\">multiple hypothesis testing<\/a> and handling <a aria-label=\"Link missing data\" href=\"https:\/\/www.editage.com\/insights\/statistical-solutions-to-overcome-missing-data-in-clinical-trials-and-observational-studies?refer=insights-search-posts\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/insights\/statistical-solutions-to-overcome-missing-data-in-clinical-trials-and-observational-studies?refer=insights-search-posts\">missing data<\/a>.\u00a0\u00a0<\/p>\n<p><a aria-label=\"Link Hobbs et al. (2022)\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35537102\/\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35537102\/\">Hobbs et al. (2022)<\/a> provide a detailed discussion of statistical issues researchers may encounter during basket trials.\u00a0\u00a0<\/p>\n<p><strong>Conclusion<\/strong>\u00a0<\/p>\n<p>Basket trials represent a promising frontier in biomedical research, offering a path to more personalized treatments and faster drug development. However, their unique nature necessitates careful statistical planning and analysis to ensure the reliability and validity of the results. By considering patient selection, endpoints, sample size, adaptive designs, and rigorous data analysis, researchers can harness the potential of basket trials and contribute to advancing precision medicine.\u00a0<\/p>\n<p>\u00a0<\/p>\n<p><i>Collaborate with statisticians experienced in basket trials and other innovative study designs! Check out Editage\u2019s <\/i><a aria-label=\"Link Statistical Analysis &amp; Review Services\" href=\"https:\/\/www.editage.com\/services\/publishing-services-packs\/statistical-analysis\" rel=\"noreferrer noopener\" target=\"_blank\" title=\"https:\/\/www.editage.com\/services\/publishing-services-packs\/statistical-analysis\">Statistical Analysis &amp; Review Services<\/a><i><u>.<\/u><\/i>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Basket trials have emerged as a promising approach in biomedical research, offering a new approach to clinical trials. These trials are particularly intriguing because they challenge the traditional way in which biomedical studies are conducted. In this blog post, we\u2019ll explore what basket trials are, their significance, and the crucial considerations for statistical analysis within [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":33313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2420,2403],"tags":[2622,2540,1319,2778,366],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-4411","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-data-analysis","category-publication-support-services","tag-analysisofdata","tag-big-data","tag-statistical-analysis","tag-statistical-analysis-and-review","tag-statistical-reporting"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Unpacking basket trials in biomedical research: A how-to 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