
{"id":522,"date":"2018-03-27T05:51:12","date_gmt":"2018-03-27T05:51:12","guid":{"rendered":"https:\/\/www.editage.com\/insights\/what-do-institutional-animal-ethics-boards-do\/"},"modified":"2025-11-25T13:22:33","modified_gmt":"2025-11-25T07:52:33","slug":"what-do-institutional-animal-ethics-boards-do","status":"publish","type":"post","link":"https:\/\/www.editage.com\/insights\/what-do-institutional-animal-ethics-boards-do","title":{"rendered":"What do institutional animal ethics boards do?"},"content":{"rendered":"<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">In the <\/span><\/span><a style=\"color: #0563c1; text-decoration: underline;\" href=\"https:\/\/www.editage.com\/insights\/the-role-of-regulatory-bodies-governing-animal-research\/\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">previous post of this series<\/span><\/span><\/a><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">, I spoke about the role of regulatory bodies governing animal research. It\u2019s now time to talk about what institutional ethics boards do when it comes to vetting animal research proposals. I\u2019ll also share tips on the things to remember when you submit your proposal for your study involving animals.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">What does an animal ethics review committee do?<\/span><\/span><\/strong><\/span><\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Studies involving animals undergo an\u00a0animal ethics review process as part of the research proposal approval process. An animal ethics committee typically\u00a0evaluates the quality and consistency of a proposal. It reviews the proposed use of animals in research by evaluating the scientific design and conduct of the study and assesses if there are any modifications required in the protocols prior to approval. The committee ensures that the protocols in the proposal adhere to the standard guidelines and the personnel involved in animal care and use are appropriately qualified to perform their duties and conduct the proposed activities. The committee also looks into any legitimate concerns involving the care and use of animals during research. The review board inspects the housing and other facilities in the animal facility in the institution to make sure that the experiments are conducted under hygienic conditions. The ethics committee assesses predictable risks\/harms to the animals to weigh them against advantage of research outcomes with every study protocol. The final decision of approval\/rejection of a research proposal and the final number of animals to be allotted is made after all committee members arrive at a consensus.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">A protocol review by an institutional animal ethics committee typically covers the following points:<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>1. <\/strong><b>The basis for approving animal research proposals:<\/b> Approvals are based on the potential contribution the research can make towards the understanding of biological or environmental principles, or issues that benefit humans, animals, and the environment. The focus is also on research that can yield reproducible results<span style=\"font-family: 'Calibri','sans-serif';\">. <\/span><\/span><\/span><\/span><\/span><\/p>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Tip:<\/span><\/span><\/u><\/i><\/strong><em><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"> Remember that approvals are granted if the researchers can provide sufficient evidence to claim that alternative methods for conducting the experiment do not exist.\u00a0<\/span><\/span><\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>2. <\/strong><b>The three Rs:<\/b> Adherence to the code of the three \u201cR\u201ds of animal research is a pre-requisite. What are the three \u201cR\u201ds? <\/span><\/span><\/span><\/span><\/p>\n<ul>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Replacement \u2013 techniques that replace the use of animals must be sought and used where possible <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Reduction \u2013 each project must use no more than the minimum number of animals necessary<\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Refinement \u2013 Projects should be designed to avoid pain and distress in animals)\u200b\u200b\u200b\u200b<\/span><\/span><\/span><\/span><\/li>\n<\/ul>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u>Tip:<\/u><\/i><\/strong><em> Make sure you follow the three Rs and specify this in your approval document.<\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>3. <\/strong><b>Plain-language summary:<\/b> Since the animal research ethics committee is supposed to include a non-scientist, a plain language summary of the project \u2013 including the primary aims, proposed use of animals, description of procedures designed to assure that animal suffering will be prevented or at least minimized \u2013 is first reviewed.<\/span><\/span><\/span><\/span><\/p>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Tip:<\/span><\/span><\/u><\/i><\/strong><em><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">\u00a0Write\u00a0a plain language summary of your project. A good way to test the effectiveness of your summary is to get a non-researcher friend to read it and share feedback on how comprehensible it was.<\/span><\/span><\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>4. <\/strong><b>Relationship between the experiment and study objectives:<\/b> The review also includes an examination of the following<\/span><\/span><\/span><\/span><\/p>\n<ul>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">The relationship between the proposed experiment and the overall objective <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Identification of the species\/strain of animals (justified by the structural, behavioural, physiological, biochemical or other features\/considerations based on previous studies) <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Approximate number of animals to be used for the experiment and appropriateness of this number [based on experimental design along with the statistical rationale which supports the size of the control and test group(s)] <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Rationale for using the animals <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Complete description of the experimental protocols to be used on animals The procedures designed to limit physical injury\/psychological distress caused to animals <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Setting of humane endpoints to the experiment <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Expertise of personnel conducting the experiments <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Use of anaesthetics, modes of surgery, analgesics, antibiotics, and euthanasia methods <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list -.25in;\"><span style=\"font-family: Calibri,sans-serif;\">Living conditions of the animals \u2013 housing, feeding, medical and non-medical care of the animals<\/span><\/span><\/span><\/span><\/li>\n<\/ul>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u>Tip:<\/u><\/i><\/strong><em> Make sure you specify how you have addressed the above points in your proposal.<\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>5. <\/strong><b>Risk analysis:<\/b> If hazardous physical, chemical, and biological agents (such as radioactive materials, recombinant DNA\/RNA, human\/plant\/animal pathogens, acute toxins, chemical carcinogens, ethers, etc.) are used, the potential health risks to humans or animals, special animal care required, precautions for personnel, special containment requirements, specific storage, waste and animal disposal requirements, and emergency procedures are reviewed extensively.<\/span><\/span><\/span><\/span><\/p>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Tip:<\/span><\/span><\/u><\/i><\/strong><em><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"> Specify in details all your procedures for handling hazardous materials, waste disposal, animal care, etc.<\/span><\/span><\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>6. <\/strong><b>Necessity:<\/b> The use of animals for teaching protocols is approved only if alternative methods such as models, videos, computer simulations and emulations, etc., do not exist.<\/span><\/span><\/span><\/span><\/p>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Tip:<\/span><\/span><\/u><\/i><\/strong><em><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"> Carefully consider the use of animals for your study. Can you perform your research without animals? If yes, then use an alternative method.<\/span><\/span><\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"><strong>7. <\/strong><b>Animal treatment:<\/b> Experimental procedures involving the capture, handling, and release of wild animals are given utmost importance. When protocols involve aspects such as population sampling by sacrificing, a strong justification is needed for the method used. These approvals are granted to researchers who have adequate experience and expertise in wildlife studies.<\/span><\/span><\/span><\/span><\/p>\n<div class=\"well\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><strong><i><u><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Tip:<\/span><\/span><\/u><\/i><\/strong><em><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\"> If you are a novice researcher, make sure\u00a0 you get the expertise of an experienced senior colleague and mention this transparently in your proposal.<\/span><\/span><\/em><\/span><\/span><\/div>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Thus, the goal of having protocols for animal experiments is to balance the ever-increasing demand of animals for medical, scientific, and economic progress, while simultaneously ensuring the ethical treatment of animals by reducing their usage and suffering. The guidelines stipulated by the government and the protocols reviewed by the institutional animal ethics committee try to reconcile these aspects and aim to achieve a cost\/benefit assessment involving ethical, scientific, and social issues. The protocols for animal usage and the committee justifies the need for animal use, thereby assuring that the expected outcome of the experiments will outweigh the cost involved and contribute positively towards scientific advancement.<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; margin-right: 0in; margin-left: 0in;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'Times New Roman',serif;\"><b><span style=\"font-size: 11.0pt;\"><span style=\"font-family: 'Calibri','sans-serif';\">Related reading:<\/span><\/span><\/b><\/span><\/span><\/p>\n<ul>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list .5in;\"><span style=\"font-family: Calibri,sans-serif;\"><a style=\"color: #0563c1; text-decoration: underline;\" href=\"https:\/\/www.gpo.gov\/fdsys\/pkg\/CFR-2005-title21-vol1\/content-detail.html\"><span style=\"color: #0563c1;\">US Government Publishing Office Food and Drug Regulations<\/span><\/a> <\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list .5in;\"><span style=\"font-family: Calibri,sans-serif;\"><a style=\"color: #0563c1; text-decoration: underline;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2213906\/\"><span style=\"color: #0563c1;\">Guidelines on Good Clinical Laboratory Practice<\/span><\/a><\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span style=\"font-size: 11pt;\"><span style=\"line-height: normal;\"><span style=\"tab-stops: list .5in;\"><span style=\"font-family: Calibri,sans-serif;\"><a style=\"color: #0563c1; text-decoration: underline;\" href=\"https:\/\/www.editage.com\/insights\/a-young-researchers-guide-to-a-clinical-trial\/\"><span style=\"color: #0563c1;\">A young researcher&#8217;s guide to a clinical trial<\/span><\/a><\/span><\/span><\/span><\/span><\/li>\n<li style=\"margin-top: 0in; margin-right: 0in; margin-bottom: .0001pt; text-align: justify; margin: 0in 0in 10pt;\"><span lang=\"EN-IN\" style=\"font-size: 11.0pt;\" xml:lang=\"EN-IN\"><span style=\"line-height: 115%;\"><span style=\"font-family: 'Calibri','sans-serif';\"><a style=\"color: #0563c1; text-decoration: underline;\" href=\"https:\/\/www.editage.com\/insights\/can-a-veterinary-medicine-paper-be-published-without-informed-consent-of-animal-owner\/\"><span style=\"color: #0563c1;\">Can a veterinary medicine paper be published without informed consent of animal owner?<\/span><\/a><\/span><\/span><\/span><\/li>\n<\/ul>\n<p><strong>Other parts in the series:<\/strong><\/p>\n<p><a href=\"https:\/\/www.editage.com\/insights\/the-role-of-regulatory-bodies-governing-animal-research\/\">Part 1:\u00a0The role of regulatory bodies governing animal research\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the previous post of this series, I spoke about the role of regulatory bodies governing animal research. It\u2019s now time to talk about what institutional ethics boards do when it comes to vetting animal research proposals. I\u2019ll also share tips on the things to remember when you submit your proposal for your study involving [&hellip;]<\/p>\n","protected":false},"author":551,"featured_media":33313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2418],"tags":[99],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-522","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-ethics","tag-ethical-guidelines"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Understanding what animal ethics review boards do | Editage Insights<\/title>\n<meta name=\"description\" content=\"This post clarifies the role and nature of animal ethics boards or regulatory bodies that set down regulations to help ensure humane and ethical 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