
{"id":17905,"date":"2017-07-10T10:26:08","date_gmt":"2017-07-10T10:26:08","guid":{"rendered":"https:\/\/www.editage.com\/insights\/research\/crispr-gene-editing-safe-or-unsafe\/"},"modified":"2025-09-22T12:27:46","modified_gmt":"2025-09-22T06:57:46","slug":"crispr-gene-editing-safe-or-unsafe","status":"publish","type":"research","link":"https:\/\/www.editage.com\/insights\/crispr-gene-editing-safe-or-unsafe","title":{"rendered":"CRISPR gene editing &#8211; safe or unsafe?"},"content":{"rendered":"<p>There hasn\u2019t been a better time for gene editing. Scientists, with help of CRISPR, a revolutionary DNA-editing tool, are trying to find a cure for most health-related concerns, big and small. Although gene editing has existed for years, it was very expensive and challenging until the cheaper and simpler CRISPR technique was discovered.<\/p>\n<p>So when a study by Columbia University Medical Center was published in May in the journal <em>Nature Methods<\/em> about this revolutionary CRISPR gene-editing technique causing unwanted and dangerous mutations, the medical community was flummoxed. The paper questioned how effective gene-editing technology is and called for a reassessment of the technique\u2019s safety. What followed could be described as fallout frenzy\u2014 stock prices of three public gene-editing companies, Editas Medicine, Intellia Therapeutics, and CRISPR Therapeutics dropped.<\/p>\n<p>However, doubts were raised by scientists affiliated with these CRISPR companies. This was mainly because the study had a small sample size of three mice. A new paper that was published in July and is available on a preprint server offers a plausible explanation for the controversial results, that is, the unwanted mutations. Two of the three study subjects, the CRISPR-edited mice, happened to be more closely related and thus shared more mutations. Therefore, the paper claimed that the premise of the old study was incorrect.<\/p>\n<p>The success of CRISPR gene editing can have a significant impact on health care as it seeks to accurately diagnose and find a cure for fatal diseases like cancer, hereditary diseases, and mosquito-borne diseases such as Zika and dengue fever. So for now, the medical profession and scientific community who are understandably excited about the potential CRISPR has can breathe a sigh of relief.<\/p>\n<p>Sources:<\/p>\n<p><a href=\"http:\/\/www.biorxiv.org\/content\/early\/2017\/07\/05\/159707\">DOI: 10.1101\/159707<\/a><br \/>\n<a href=\"http:\/\/dx.doi.org\/10.1016\/j.cell.2017.05.044\" target=\"_blank\" rel=\"noopener\">DOI: 10.1016\/j.cell.2017.05.044<\/a><\/p>\n","protected":false},"author":318,"featured_media":33313,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"new_tags":[],"series":[],"subject":[2976,2974,2975],"class_list":["post-17905","research","type-research","status-publish","has-post-thumbnail","hentry","subject-and-molecular-biology","subject-biochemistry","subject-genetics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CRISPR gene editing - safe or unsafe? | Editage Insights<\/title>\n<meta name=\"description\" content=\"There hasn\u2019t been a better time for gene editing. 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