{"id":18219,"date":"2014-06-24T07:54:27","date_gmt":"2014-06-24T07:54:27","guid":{"rendered":"https:\/\/www.editage.com\/insights\/research\/protein-clumps-spread-inflammation\/"},"modified":"2025-09-19T16:16:20","modified_gmt":"2025-09-19T10:46:20","slug":"protein-clumps-spread-inflammation","status":"publish","type":"research","link":"https:\/\/www.editage.com\/insights\/protein-clumps-spread-inflammation","title":{"rendered":"Protein clumps spread inflammation"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family: verdana,geneva,sans-serif;\"><span style=\"font-size: 14px;\">Two research teams based in Germany and Spain have discovered that ASC specks\u2014protein aggregations that drive inflammation\u2014are released from dying immune cells. The protein aggregations are a component of inflammasomes, which sense pathogens and cell damage and set off innate immune inflammation. Researchers previously thought inflammasomes acted only inside single cells, but according to the latest finding, the ASC specks can effect extracellular inflammation. The teams also found that macrophages can take up released ASC specks, perpetuating the immune response. Their findings help explain the mystery of how relatively localized contact between a cell and a pathogen or product of cell damage can lead to widespread inflammation.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: verdana,geneva,sans-serif;\"><span style=\"font-size: 14px;\">Read in detail in <em><a href=\"http:\/\/www.the-scientist.com\/?articles.view\/articleNo\/40313\/title\/Protein-Clumps-Spread-Inflammation\/\">Scientific American<\/a><\/em>.\u00a0<\/span><\/span><\/p>\n","protected":false},"author":8,"featured_media":33313,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"new_tags":[],"series":[],"subject":[2976,2974,2975],"class_list":["post-18219","research","type-research","status-publish","has-post-thumbnail","hentry","subject-and-molecular-biology","subject-biochemistry","subject-genetics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Protein clumps spread inflammation | Editage Insights<\/title>\n<meta name=\"description\" content=\"Two research teams based in Germany and Spain have discovered that ASC specks\u2014protein aggregations that drive inflammation\u2014are released from dying immune cells. The protein aggregations are a component of inflammasomes, which sense pathogens and cell damage and set off innate immune inflammation. Read on to know more.\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.editage.com\/insights\/protein-clumps-spread-inflammation\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protein clumps spread inflammation | Editage Insights\" \/>\n<meta property=\"og:description\" content=\"Two research teams based in Germany and Spain have discovered that ASC specks\u2014protein aggregations that drive inflammation\u2014are released from dying immune cells. The protein aggregations are a component of inflammasomes, which sense pathogens and cell damage and set off innate immune inflammation. 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