{"id":18251,"date":"2014-11-27T12:59:23","date_gmt":"2014-11-27T12:59:23","guid":{"rendered":"https:\/\/www.editage.com\/insights\/research\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system\/"},"modified":"2025-09-19T16:05:00","modified_gmt":"2025-09-19T10:35:00","slug":"a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system","status":"publish","type":"research","link":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system","title":{"rendered":"A new human interactome map created using the yeast two-hybrid system"},"content":{"rendered":"

Although researchers have succeeded in sequencing the human genome, to expand the knowledge of functional elements within the genome, a thorough study of how human proteins operate and interact is essential. Researchers at the Dana-Farber Cancer Institute\u2019s Center for Cancer Systems Biology have made a detailed study of genome functioning possible by creating a new\u00a0human interactome map<\/a>. The map is based on a systematic screen of 13,000 human proteins that revealed 14,000 pairwise interactions. The researchers have documented about 5 percent to 10 percent of all the protein-protein interactions that exist using the yeast two-hybrid system<\/a>. This comprehensive study can prove to be valuable in the study of chronic diseases such as cancer.<\/span><\/span><\/p>\n

Read more in The Scientist<\/a><\/em>. \u00a0<\/span><\/span><\/p>\n","protected":false},"author":8,"featured_media":33313,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"new_tags":[],"series":[],"subject":[2976,2974,2975],"class_list":["post-18251","research","type-research","status-publish","has-post-thumbnail","hentry","subject-and-molecular-biology","subject-biochemistry","subject-genetics"],"acf":[],"yoast_head":"\nA new human interactome map created using the yeast two-hybrid system | Editage Insights<\/title>\n<meta name=\"description\" content=\"Although researchers have succeeded in sequencing the human genome, a thorough study of how human proteins operate and interact is essential. A group of researchers\u00a0has made this possible by creating a new\u00a0human interactome map. Read on to find out more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new human interactome map created using the yeast two-hybrid system | Editage Insights\" \/>\n<meta property=\"og:description\" content=\"Although researchers have succeeded in sequencing the human genome, a thorough study of how human proteins operate and interact is essential. A group of researchers\u00a0has made this possible by creating a new\u00a0human interactome map. Read on to find out more.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system\" \/>\n<meta property=\"og:site_name\" content=\"Editage Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Editage\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-19T10:35:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/06\/editage-insights-generic-banner.png\" \/>\n\t<meta property=\"og:image:width\" content=\"870\" \/>\n\t<meta property=\"og:image:height\" content=\"446\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Editage\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system\",\"url\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system\",\"name\":\"A new human interactome map created using the yeast two-hybrid system | Editage Insights\",\"isPartOf\":{\"@id\":\"https:\/\/www.editage.com\/insights\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp\",\"datePublished\":\"2014-11-27T12:59:23+00:00\",\"dateModified\":\"2025-09-19T10:35:00+00:00\",\"description\":\"Although researchers have succeeded in sequencing the human genome, a thorough study of how human proteins operate and interact is essential. A group of researchers\u00a0has made this possible by creating a new\u00a0human interactome map. Read on to find out more.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#primaryimage\",\"url\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp\",\"contentUrl\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp\",\"width\":656,\"height\":336},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.editage.com\/insights\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researchs\",\"item\":\"https:\/\/www.editage.com\/insights\/research\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"A new human interactome map created using the yeast two-hybrid system\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.editage.com\/insights\/#website\",\"url\":\"https:\/\/www.editage.com\/insights\/\",\"name\":\"Editage Insights\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.editage.com\/insights\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.editage.com\/insights\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.editage.com\/insights\/#organization\",\"name\":\"Editage Insights\",\"url\":\"https:\/\/www.editage.com\/insights\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.editage.com\/insights\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2024\/09\/editage-insights-logo-1-scaled.webp\",\"contentUrl\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2024\/09\/editage-insights-logo-1-scaled.webp\",\"width\":2560,\"height\":324,\"caption\":\"Editage Insights\"},\"image\":{\"@id\":\"https:\/\/www.editage.com\/insights\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/Editage\",\"https:\/\/x.com\/Editage\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new human interactome map created using the yeast two-hybrid system | Editage Insights","description":"Although researchers have succeeded in sequencing the human genome, a thorough study of how human proteins operate and interact is essential. A group of researchers\u00a0has made this possible by creating a new\u00a0human interactome map. Read on to find out more.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system","og_locale":"en_US","og_type":"article","og_title":"A new human interactome map created using the yeast two-hybrid system | Editage Insights","og_description":"Although researchers have succeeded in sequencing the human genome, a thorough study of how human proteins operate and interact is essential. A group of researchers\u00a0has made this possible by creating a new\u00a0human interactome map. Read on to find out more.","og_url":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system","og_site_name":"Editage Insights","article_publisher":"https:\/\/www.facebook.com\/Editage","article_modified_time":"2025-09-19T10:35:00+00:00","og_image":[{"width":870,"height":446,"url":"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/06\/editage-insights-generic-banner.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_site":"@Editage","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system","url":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system","name":"A new human interactome map created using the yeast two-hybrid system | Editage Insights","isPartOf":{"@id":"https:\/\/www.editage.com\/insights\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#primaryimage"},"image":{"@id":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#primaryimage"},"thumbnailUrl":"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp","datePublished":"2014-11-27T12:59:23+00:00","dateModified":"2025-09-19T10:35:00+00:00","description":"Although researchers have succeeded in sequencing the human genome, a thorough study of how human proteins operate and interact is essential. A group of researchers\u00a0has made this possible by creating a new\u00a0human interactome map. Read on to find out more.","breadcrumb":{"@id":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#primaryimage","url":"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp","contentUrl":"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp","width":656,"height":336},{"@type":"BreadcrumbList","@id":"https:\/\/www.editage.com\/insights\/a-new-human-interactome-map-created-using-the-yeast-two-hybrid-system#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.editage.com\/insights\/"},{"@type":"ListItem","position":2,"name":"Researchs","item":"https:\/\/www.editage.com\/insights\/research"},{"@type":"ListItem","position":3,"name":"A new human interactome map created using the yeast two-hybrid system"}]},{"@type":"WebSite","@id":"https:\/\/www.editage.com\/insights\/#website","url":"https:\/\/www.editage.com\/insights\/","name":"Editage Insights","description":"","publisher":{"@id":"https:\/\/www.editage.com\/insights\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.editage.com\/insights\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.editage.com\/insights\/#organization","name":"Editage Insights","url":"https:\/\/www.editage.com\/insights\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.editage.com\/insights\/#\/schema\/logo\/image\/","url":"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2024\/09\/editage-insights-logo-1-scaled.webp","contentUrl":"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2024\/09\/editage-insights-logo-1-scaled.webp","width":2560,"height":324,"caption":"Editage Insights"},"image":{"@id":"https:\/\/www.editage.com\/insights\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Editage","https:\/\/x.com\/Editage"]}]}},"_links":{"self":[{"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/research\/18251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/types\/research"}],"author":[{"embeddable":true,"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/users\/8"}],"version-history":[{"count":0,"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/research\/18251\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/media\/33313"}],"wp:attachment":[{"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/media?parent=18251"}],"wp:term":[{"taxonomy":"new_tags","embeddable":true,"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/new_tags?post=18251"},{"taxonomy":"series","embeddable":true,"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/series?post=18251"},{"taxonomy":"subject","embeddable":true,"href":"https:\/\/www.editage.com\/insights\/wp-json\/wp\/v2\/subject?post=18251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}