{"id":18323,"date":"2015-03-04T11:14:11","date_gmt":"2015-03-04T11:14:11","guid":{"rendered":"https:\/\/www.editage.com\/insights\/research\/a-new-mitochondrial-derived-hormone-supresses-obesity-and-insulin-resistance\/"},"modified":"2025-09-22T10:55:54","modified_gmt":"2025-09-22T05:25:54","slug":"a-new-mitochondrial-derived-hormone-supresses-obesity-and-insulin-resistance","status":"publish","type":"research","link":"https:\/\/www.editage.com\/insights\/a-new-mitochondrial-derived-hormone-supresses-obesity-and-insulin-resistance","title":{"rendered":"A new mitochondrial-derived hormone supresses obesity and insulin resistance"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">A team of researchers from the USC Leonard Davis School of Gerontology\u00a0has discovered a new hormone \u201cMOTS-c,\u201d\u00a0<\/span><span style=\"font-size: 14px;\">a mitochondrial-derived peptide hormone<\/span><span style=\"font-size: 14px;\">\u00a0that imitates the effects commonly associated with exercising. It counters insulin insensitivity and diet-induced and age-dependent insulin resistance. Researchers tested the efficacy of the hormone by injecting it in mice that were on a high-fat diet, a precursor to obesity and insulin resistance. However, MOTS-c was able to suppress these effects. The uniqueness of MOTS-c is that while hormones are typically encoded in DNA in the nucleus, MOTS-c originates in the DNA of mitochondria that are the &#8220;powerhouses&#8221; of cells that convert food into energy. According to Changhan Lee, assistant professor at USC Davis and lead author of the study, \u201cThis discovery sheds new light on mitochondria and positions them as active regulators of metabolism.\u201d While the hormone has only been tested on mice, it would be tested on human in a few years.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">Read more <em><a href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/03\/150303183407.htm\">Science Daily<\/a><\/em>. \u00a0\u00a0<\/span><\/p>\n","protected":false},"author":8,"featured_media":33313,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"new_tags":[],"series":[],"subject":[2976,2974,2975],"class_list":["post-18323","research","type-research","status-publish","has-post-thumbnail","hentry","subject-and-molecular-biology","subject-biochemistry","subject-genetics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new mitochondrial-derived hormone supresses obesity and insulin resistance | Editage Insights<\/title>\n<meta name=\"description\" content=\"A team of researchers from the USC Leonard Davis School of Gerontology\u00a0has discovered a new hormone \u201cMOTS-c,\u201d\u00a0a mitochondrial-derived peptide hormone\u00a0that imitates the effects commonly associated with exercising. It counters insulin insensitivity and diet-induced and age-dependent insulin resistance. Read on to find out more.\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.editage.com\/insights\/a-new-mitochondrial-derived-hormone-supresses-obesity-and-insulin-resistance\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new mitochondrial-derived hormone supresses obesity and insulin resistance | Editage Insights\" \/>\n<meta property=\"og:description\" content=\"A team of researchers from the USC Leonard Davis School of Gerontology\u00a0has discovered a new hormone \u201cMOTS-c,\u201d\u00a0a mitochondrial-derived peptide hormone\u00a0that imitates the effects commonly associated with exercising. It counters insulin insensitivity and diet-induced and age-dependent insulin resistance. 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