{"id":18407,"date":"2015-12-07T13:08:33","date_gmt":"2015-12-07T13:08:33","guid":{"rendered":"https:\/\/www.editage.com\/insights\/research\/combining-opioid-peptides-and-nav1-7-blockers-can-obstruct-pain\/"},"modified":"2025-09-22T10:36:10","modified_gmt":"2025-09-22T05:06:10","slug":"combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain","status":"publish","type":"research","link":"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain","title":{"rendered":"Combining opioid peptides and Nav1.7 blockers can obstruct pain"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">Nav1.7<\/span><span style=\"font-size: 14px;\">\u00a0plays an important role in pain pathways, and i<\/span><span style=\"font-size: 14px;\">ndividuals born with non-functioning Nav1.7 fail to experience pain. Although\u00a0<\/span><span style=\"font-size: 14px;\">scientists have developed drugs that would block Nav1.7 in an attempt to block pain, they have met with little success. R<\/span><span style=\"font-size: 14px;\">researchers from University College London did further research on designing a new treatment for eliminating the feeling of pain. They<\/span><span style=\"font-size: 14px;\">\u00a0made a significant observation that transgenetic mice with\u00a0<\/span><span style=\"font-size: 14px;\">non-functioning<\/span><span style=\"font-size: 14px;\">\u00a0Nav1.7\u00a0<\/span><span style=\"font-size: 14px;\">produced more opioid peptides than those with functioning Nav1.7 did. To test whether opioids are also responsible for cutting off pain, they gave the mice an opioide blocker, naloxone, and they found that Nav1.7 lacking mice became capable of feeling pain. The study confirmed that Nav1.7 and opioids together play an important role in painlessness. The team now hopes to get a patent on a novel treatment for pain management by combining low doses of opoids and Nav1.7 blockers. Moreover, this treatment has an edge over conventional opioid painkillers such as morphine that are damaging to humans when used over a long period of time.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;\">Read more in <em><a href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/12\/151204090034.htm\">Science Daily<\/a><\/em>. \u00a0\u00a0<\/span><\/p>\n","protected":false},"author":8,"featured_media":33313,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"new_tags":[],"series":[],"subject":[2976,2974,2975],"class_list":["post-18407","research","type-research","status-publish","has-post-thumbnail","hentry","subject-and-molecular-biology","subject-biochemistry","subject-genetics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Combining opioid peptides and Nav1.7 blockers can obstruct pain | Editage Insights<\/title>\n<meta name=\"description\" content=\"Nav1.7\u00a0plays an important role in pain pathways, and individuals born with non-functioning Nav1.7 fail to experience pain. Although\u00a0scientists have developed drugs that would block Nav1.7 in an attempt to block pain, they have met with little success. Researchers from University College London did further research on designing a new treatment for eliminating the feeling of pain. Read more about their research here.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Combining opioid peptides and Nav1.7 blockers can obstruct pain | Editage Insights\" \/>\n<meta property=\"og:description\" content=\"Nav1.7\u00a0plays an important role in pain pathways, and individuals born with non-functioning Nav1.7 fail to experience pain. Although\u00a0scientists have developed drugs that would block Nav1.7 in an attempt to block pain, they have met with little success. Researchers from University College London did further research on designing a new treatment for eliminating the feeling of pain. Read more about their research here.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain\" \/>\n<meta property=\"og:site_name\" content=\"Editage Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Editage\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-22T05:06:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/06\/editage-insights-generic-banner.png\" \/>\n\t<meta property=\"og:image:width\" content=\"870\" \/>\n\t<meta property=\"og:image:height\" content=\"446\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Editage\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain\",\"url\":\"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain\",\"name\":\"Combining opioid peptides and Nav1.7 blockers can obstruct pain | Editage Insights\",\"isPartOf\":{\"@id\":\"https:\/\/www.editage.com\/insights\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.editage.com\/insights\/combining-opioid-peptides-and-nav17-blockers-can-obstruct-pain#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.editage.com\/insights\/wp-content\/uploads\/2025\/02\/editage-insights-generic-banner_298.webp\",\"datePublished\":\"2015-12-07T13:08:33+00:00\",\"dateModified\":\"2025-09-22T05:06:10+00:00\",\"description\":\"Nav1.7\u00a0plays an important role in pain pathways, and individuals born with non-functioning Nav1.7 fail to experience pain. 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