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Can you help me understand a sentence that the reviewer wants me to correct?

Which of the following expressions is correct?

1. Suppressor of cytokine signaling 3a is a member of the suppressor of cytokine signaling family and it has been shown to be involved in physiological stress of zebrafish.

2. Suppressor of cytokine signaling 3a is a member of the suppressor of cytokine signaling family. It has shown that it involves in physiological stress of zebrafish.

3. Suppressor of cytokine signaling 3a is a member of the suppressor of cytokine signaling family. It is shown that it involves in physiological stress of zebrafish .

Could you explain what each statement actually means. The reviewer has asked me to revise the second sentence. What is wrong in that sentence? Also explain the other sentences.

This is a very subject-specific question, I would not be able to comment on the meaning. I can only comment on the grammatical and stylistic aspects. Out of the three sentences mentioned in your question, only the first is clear and grammatically correct. The latter part of the second one is incorrect: "It has shown that it involves in physiological stress of zebrafish." It can be corrected to "It has been shown that it is involved in physiological stress of zebrafish." The phrase "it involves in" is awkward.  "Involves" is a transitive verb and therefore needs an object. However, the object is missing here. In addition to this problem, the third sentence also uses "This is shown." The simple present tense is not applicable here as this tense is generally used for things that happen regularly. But here, you are referring to an action that has just been completed; hence the present perfect tense "has been" is more appropriate.

Suppressor of cytokine signaling 3a is a member of the suppressor of cytokine signaling family and it has been shown to be involved in physiological stress of zebrafish. COULD YOU EXPLAIN HOW TO CHANGE THIS INTO ACTIVE VOICE

I must take issue with the first answer given to Mr. Rajasekar. Sample 1 is not grammatically correct. There must be a comma placed before the coordinating conjunction "and" because the remainder of the sentence is a complete sentence in and of itself (it contains both a subject and a verb).
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